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  1. Mammalian oocytes accumulate more than ten thousand mRNAs, of which three to four thousand mRNAs are translationally repressed. The timings and sites of translational activation of these dormant mRNAs are cruc...

    Authors: Takahiro Sanada and Tomoya Kotani
    Citation: Biological Procedures Online 2024 26:23
  2. Peste des petits ruminants (PPRV), a highly contagious viral disease, causes significant economic losses concerning sheep and goats. Recently, PPR viruses (PPRVs), have adopted new hosts and lineage IV of PPRV...

    Authors: Tahira Kamal, Saeed-ul-Hassan Khan, Fariha Hassan, Amir-bin- Zahoor, Amman Ullah, S. Murtaza Hassan Andrabi, Ghulam Muhammad Ali, Tayyaba Afsar, Fohad Mabood Husain, Huma Shafique and Suhail Razak
    Citation: Biological Procedures Online 2024 26:22
  3. The role of tumor inflammatory microenvironment in the advancement of cancer, particularly prostate cancer, is widely acknowledged. ELL-associated factor 2 (EAF2), a tumor suppressor that has been identified i...

    Authors: Tianyu Cao, Qian Sun, Xiaoqin Shi, Xiuke Lin, Qingyuan Lin, Jinchao Zhu, Junhao Xu, Di Cui, Youwei Shi, Yifeng Jing and Wenhuan Guo
    Citation: Biological Procedures Online 2024 26:21
  4. Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, and affects large regions of Asia, Southwestern and Southeastern Europe, and Africa. CCHFV can produce symptoms, including no ...

    Authors: Khursheed Muzammil, Saba Rayyani, Ahmed Abbas Sahib, Omid Gholizadeh, Hayder Naji Sameer, Tareq Jwad Kazem, Haneen Badran Mohammed, Hesam Ghafouri Kalajahi, Rahadian Zainul and Saman Yasamineh
    Citation: Biological Procedures Online 2024 26:20
  5. Age-related macular degeneration (AMD) is a leading cause of blindness, affecting millions worldwide. Its complex pathogenesis involves a variety of risk factors, including lipid metabolism and inflammation. T...

    Authors: Wang Jingzhi and Xuehao Cui
    Citation: Biological Procedures Online 2024 26:19
  6. The lack of standardized protocols for isolating extracellular vesicles (EVs), especially from biobank-stored blood plasma, translates to limitations for the study of new biomarkers. This study examines whethe...

    Authors: Ana Torres, Lorena Bernardo, Carmen Sánchez, Esperanza Morato, Jose Carlos Solana and Eugenia Carrillo
    Citation: Biological Procedures Online 2024 26:18
  7. Culex pipiens L. is a principal vector of zoonotic arboviruses in Europe, acting in both an amplification role in enzootic transmission between avian hosts and as a bridge vector between avian hosts and mammals. ...

    Authors: Laura Jones, Christopher Sanders, Marion England, Mary Cameron and Simon Carpenter
    Citation: Biological Procedures Online 2024 26:17
  8. It is necessary to develop advanced therapies utilizing natural ingredients with anti-inflammatory qualities in order to lessen the negative effects of chemotherapeutics.

    Authors: Dalia Medhat, Mona A. El-Bana, Ibrahim El-Tantawy El-Sayed, Abdullah A. S. Ahmed, Mehrez E. El-Naggar and Jihan Hussein
    Citation: Biological Procedures Online 2024 26:16
  9. Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. Exosomes can be derived from cancer cells as well as cellular components in tumor microenvironment....

    Authors: Yating Wu, Yue Cao, Li Chen, Xiaofeng Lai, Shenghang Zhang and Shuiliang Wang
    Citation: Biological Procedures Online 2024 26:15
  10. Extracellular vesicles (EVs) are nano-sized, membranous transporters of various active biomolecules with inflicting phenotypic capabilities, that are naturally secreted by almost all cells with a promising van...

    Authors: Nico G. Menjivar, Jaiden Oropallo, Samuel Gebremedhn, Luca A. Souza, Ahmed Gad, Christian M. Puttlitz and Dawit Tesfaye
    Citation: Biological Procedures Online 2024 26:14
  11. Pseudomyxoma peritonei (PMP) is a rare peritoneal mucinous carcinomatosis with largely unknown underlying molecular mechanisms. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is ...

    Authors: Antonio Romero-Ruiz, Melissa Granados-Rodríguez, Florina I. Bura, Francisca Valenzuela-Molina, Blanca Rufián-Andújar, Ana Martínez-López, Lidia Rodríguez-Ortiz, Rosa Ortega-Salas, María Torres-Martínez, Ana Moreno-Serrano, Justo Castaño, Carmen Michán, José Alhama, Mari C. Vázquez-Borrego and Álvaro Arjona-Sánchez
    Citation: Biological Procedures Online 2024 26:13
  12. Lung adenocarcinoma metastasizing to the brain results in a notable increase in patient mortality. The high incidence and its impact on survival presents a critical unmet need to develop an improved understand...

    Authors: Jianing Chen, Congli Hu, Hainan Yang, Li Wang, Xiangling Chu, Xin Yu, Shiji Zhang, Xuefei Li, Chao Zhao, Lei Cheng, Weiping Hong, Da Liu, Lei Wen and Chunxia Su
    Citation: Biological Procedures Online 2024 26:12
  13. The efficacy of oncolytic viruses (OV) in cancer treatment depends on their ability to successfully infect and destroy tumor cells. However, patients’ tumors vary, and in the case of individual insensitivity t...

    Authors: Leslie Elsner, Lisanne Heimann, Anja Geisler, Babette Dieringer, Klaus-Peter Knoch, Luisa Hinze, Karin Klingel, Michel Solimena, Jens Kurreck and Henry Fechner
    Citation: Biological Procedures Online 2024 26:11
  14. Neoadjuvant therapy followed by surgery has become the standard of care for locally advanced esophageal squamous cell carcinoma (ESCC) and accurate pathological response assessment is critical to assess the th...

    Authors: Yichen Wang, Wenhua Zhang, Lijun Chen, Jun Xie, Xuebin Zheng, Yan Jin, Qiang Zheng, Qianqian Xue, Bin Li, Chuan He, Haiquan Chen and Yuan Li
    Citation: Biological Procedures Online 2024 26:10
  15. MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), original found in synthetic heroin, causes Parkinson’s disease (PD) in human through its metabolite MPP+ by inhibiting complex I of mitochondrial respiratory c...

    Authors: Hongzhi Li, Jing Zhang, Yuqi Shen, Yifan Ye, Qingyou Jiang, Lan Chen, Bohao Sun, Zhuo Chen, Luxi Shen, Hezhi Fang, Jifeng Yang and Haihua Gu
    Citation: Biological Procedures Online 2024 26:9
  16. Osteoclasts are the tissue-specific macrophage population of the bone and unique in their bone-resorbing activity. Hence, they are fundamental for bone physiology in health and disease. However, efficient prot...

    Authors: Suganja Chandrabalan, Linh Dang, Uwe Hansen, Melanie Timmen, Corinna Wehmeyer, Richard Stange, Tim Beißbarth, Claudia Binder, Annalen Bleckmann and Kerstin Menck
    Citation: Biological Procedures Online 2024 26:7
  17. Metal–organic frameworks (MOFs) are porous materials with unique characteristics that make them well-suited for drug delivery and gene therapy applications. Among the MOFs, zeolitic imidazolate framework-8 (ZI...

    Authors: Marzieh Sameni, Parisa Moradbeigi, Sara Hosseini, Sayyed Mohammad Hossein Ghaderian, Vahid Jajarmi, Amir Hossein Miladipour, Hojat Basati, Maryam Abbasi and Mohammad Salehi
    Citation: Biological Procedures Online 2024 26:4
  18. Generating targeted mutant mice is a crucial technology in biomedical research. This study focuses on optimizing the CRISPR/Cas9 system uptake into sperm cells using the methyl β-cyclodextrin-sperm-mediated ge...

    Authors: Parisa Moradbeigi, Sara Hosseini, Mohammad Salehi and Asghar Mogheiseh
    Citation: Biological Procedures Online 2024 26:3

    The Correction to this article has been published in Biological Procedures Online 2024 26:5

  19. Some of the most complex surgical interventions to treat trauma and cancer include the use of locoregional pedicled and free autologous tissue transfer flaps. While the techniques used for these reconstructive...

    Authors: Edita Aksamitiene, Ryan N. Heffelfinger, Jan B. Hoek and Edmund deAzevedo Pribitkin
    Citation: Biological Procedures Online 2024 26:2
  20. Gastric cancer (GC) is a common malignancy and a leading cause of cancer-related death with high morbidity and mortality. Methyl-CpG binding domain protein 3 (MBD3), a key epigenetic regulator, is abnormally e...

    Authors: Huizhi Wang, Jingyu Min, Yuntao Ding, Zhengyue Yu, Yujing Zhou, Shunyu Wang, Aihua Gong and Min Xu
    Citation: Biological Procedures Online 2024 26:1
  21. The action of mesenchymal stem cells (MSCs) is the subject of intense research in the field of regenerative medicine, including their potential use in companion animals, such as dogs. To ensure the safety of c...

    Authors: Emese Pekker, Katalin Priskin, Éva Szabó-Kriston, Bernadett Csányi, Orsolya Buzás-Bereczki, Lili Adorján, Valéria Szukacsov, Lajos Pintér, Miklós Rusvai, Paul Cooper, Endre Kiss-Tóth and Lajos Haracska
    Citation: Biological Procedures Online 2023 25:33
  22. Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cancers. Accumulating evidence suggests that inducing ferroptosis of tumor cells can inhibit...

    Authors: Xiaole Meng, Xiao Peng, Wanxin Ouyang, Hui Li, Risi Na, Wenting Zhou, Xuting You, Yuhuan Li, Xin Pu, Ke Zhang, Junjie Xia, Jie Wang, Guohong Zhuang, Huamei Tang and Zhihai Peng
    Citation: Biological Procedures Online 2023 25:32
  23. Ischemic stroke (IS) occurs when a blood vessel supplying the brain becomes obstructed, resulting in cerebral ischemia. This type of stroke accounts for approximately 87% of all strokes. Globally, IS leads to ...

    Authors: Yaowen Luo, Junkai Cheng, Yihao Fu, Min Zhang, Maorong Gou, Juan Li, Xiaobing Li, Jing Bai, Yuefei Zhou, Lei Zhang and Dakuan Gao
    Citation: Biological Procedures Online 2023 25:30
  24. Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propensity for metastasis. Patients diagnosed with localized primary cancer have higher survi...

    Authors: Bin Luo, Zujun Que, Xinyi Lu, Dan Qi, Zhi Qiao, Yun Yang, Fangfang Qian, Yi Jiang, Yan Li, Ronghu Ke, Xiaoyun Shen, Hua Xiao, Hegen Li, Erxi Wu and Jianhui Tian
    Citation: Biological Procedures Online 2023 25:29
  25. Extracellular vesicles (EVs) are nanoscale vesicles derived from cells that mediate intercellular communication by transporting bioactive molecules. They play significant roles in various physiological and pat...

    Authors: Li Wang, Xin Yu, Juan Zhou and Chunxia Su
    Citation: Biological Procedures Online 2023 25:28
  26. Arthropods transmit a wide range of pathogens of importance for the global health of humans, animals, and plants. One group of these arthropod vectors, Culicoides biting midges (Diptera: Ceratopogonidae), is the ...

    Authors: Marc Guimerà Busquets, Faye V. Brown, Simon T. Carpenter, Karin E. Darpel and Christopher J. Sanders
    Citation: Biological Procedures Online 2023 25:27
  27. Astrocytes have recently gained attention as key contributors to the pathogenesis of neurodegenerative disorders including Parkinson’s disease. To investigate human astrocytes in vitro, numerous differentiatio...

    Authors: Patrycja Mulica, Carmen Venegas, Zied Landoulsi, Katja Badanjak, Sylvie Delcambre, Maria Tziortziou, Soraya Hezzaz, Jenny Ghelfi, Semra Smajic, Jens Schwamborn, Rejko Krüger, Paul Antony, Patrick May, Enrico Glaab, Anne Grünewald and Sandro L. Pereira
    Citation: Biological Procedures Online 2023 25:26
  28. Exosomes, a special subtype of extracellular vesicles derived from human cells, serve as vital mediators of intercellular communication by transporting diverse bioactive cargos, including proteins and enzymes....

    Authors: Christopher Olson, Pengyang Zhang, Joy Ku, Renceh Flojo, Darin Boyes and Biao Lu
    Citation: Biological Procedures Online 2023 25:25
  29. In view of the limited data on radiotherapy (RT) combined with immunotherapy in patients with extensive-stage small cell lung cancer (ES-SCLC), this study aimed to identify the immune activation effect on diff...

    Authors: Min Wu, Shihao Wu, Yuetong Chen, Liangchao Sun and Jundong Zhou
    Citation: Biological Procedures Online 2023 25:24
  30. The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the SARS-CoV-2 Spike protein via the receptor binding domain (RBD) to human angio...

    Authors: Shine Varghese Jancy, Santhik Subhasingh Lupitha, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Shijulal Nelson-Sathi, Roshny Prasad, Sara Jones, Sreekumar Easwaran, Pramod Darvin, Aswathy Sivasailam and Thankayyan Retnabai Santhoshkumar
    Citation: Biological Procedures Online 2023 25:22
  31. Clinical studies suggest that immune checkpoint inhibitor (ICI) monotherapy has limited benefits in non-small cell lung cancer (NSCLC) patients after epidermal growth factor receptor-tyrosine kinase inhibitor ...

    Authors: Juan Zhou, Xiangling Chu, Jing Zhao, Mengqing Xie, Jing Wu, Xin Yu, Yujia Fang, Yazhou Li, Xiyan Li and Chunxia Su
    Citation: Biological Procedures Online 2023 25:21
  32. The incidence and mortality of gastric cancer (GC) are high worldwide. Tumor stemness is a major contributor to tumorigenesis and development of GC, in which long non-coding RNAs (lncRNAs) are deeply involved....

    Authors: Xia Hu, Maoyuan Zhao, Shuangyuan Hu, Qingsong Liu, Wenhao Liao, Lina Wan, Feng Wei, Fangting Su, Yu Guo and Jinhao Zeng
    Citation: Biological Procedures Online 2023 25:20
  33. Resistance to HER2-targeted therapies, including the monoclonal antibody trastuzumab and tyrosine kinase inhibitor lapatinib, frequently occurs and currently represents a significant clinical challenge in the ...

    Authors: Hao Liu, Sanbao Ruan, Margaret E. Larsen, Congcong Tan, Bolin Liu and Hui Lyu
    Citation: Biological Procedures Online 2023 25:19
  34. One of the most prominent questions in the field of transgenesis is ‘Where in the genome to integrate a transgene?’. Escape from epigenetic silencing and promoter shutdown of the transgene needs reliable genom...

    Authors: Nima Dehdilani, Lena Goshayeshi, Sara Yousefi Taemeh, Ahmad Reza Bahrami, Sylvie Rival Gervier, Bertrand Pain and Hesam Dehghani
    Citation: Biological Procedures Online 2023 25:18
  35. Deinococcus radiodurans is a robust bacterium that can withstand harsh environments that cause oxidative stress to macromolecules due to its cellular structure and physiological functions. Cells release extracell...

    Authors: Jeong Moo Han, Ha-Yeon Song, Jong-Hyun Jung, Sangyong Lim, Ho Seong Seo, Woo Sik Kim, Seung-Taik Lim and Eui-Baek Byun
    Citation: Biological Procedures Online 2023 25:17
  36. Immunotherapy is effective only in limited patients. It is urgent to discover a novel biomarker to predict immune cells infiltration status and immunotherapy response of different cancers. CLSPN has been repor...

    Authors: Yihong Chen, Haicheng Wen, Yin Li, Ying Han, Jun Tan, Cao Guo, Changjing Cai, Ping Liu, Yinghui Peng, Yihan Liu, Xinwen Wang, Shan Zeng, Ziyang Feng and Hong Shen
    Citation: Biological Procedures Online 2023 25:16
  37. Deep learning has been extensively used in digital histopathology. The purpose of this study was to test deep learning (DL) algorithms for predicting the vital status of whole-slide image (WSI) of uveal melano...

    Authors: Qi Wan, Xiang Ren, Ran Wei, Shali Yue, Lixiang Wang, Hongbo Yin, Jing Tang, Ming Zhang, Ke Ma and Ying-ping Deng
    Citation: Biological Procedures Online 2023 25:15
  38. The treatment efficacy of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) varies widely between individuals. The aim of this study was to identify subtype landscapes and responser rel...

    Authors: Bufu Tang, Yajie Wang, Jinyu Zhu, Jingjing Song, Shiji Fang, Qiaoyou Weng, Yang Yang, Jianfei Tu, Zhongwei Zhao, Minjiang Chen, Min Xu, Weiqian Chen and Jiansong Ji
    Citation: Biological Procedures Online 2023 25:13
  39. Authors: Pardis Yousefi Talouki, Saeed Hesami Tackallou, Shahrokh Shojaei, Soheila Zamanlui Benisi and Vahabodin Goodarzi
    Citation: Biological Procedures Online 2023 25:12

    The original article was published in Biological Procedures Online 2023 25:9

  40. Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children, which is highly prone to bone marrow (BM) metastasis. BM can monitor early signs of mild disease and metastasis. Existing b...

    Authors: Chiyi Jiang, Yeran Yang, Sidou He, Zhixia Yue, Tianyu Xing, Ping Chu, Wenfa Yang, Hui Chen, Xiaoxi Zhao, Yongbo Yu, Xuan Zhang, Yan Su, Yongli Guo and Xiaoli Ma
    Citation: Biological Procedures Online 2023 25:11
  41. Sepsis-related acute kidney injury (AKI) is an inflammatory disease associated with extremely high mortality and health burden. This study explored the possibility of exosomes secreted by adipose-derived mesen...

    Authors: Wei Liu, Chenghuan Hu, Buyao Zhang, Mingxia Li, Fuxing Deng and Shuangping Zhao
    Citation: Biological Procedures Online 2023 25:10
  42. Tissue engineering for cartilage regeneration has made great advances in recent years, although there are still challenges to overcome. This study aimed to evaluate the chondrogenic differentiation of human ad...

    Authors: Pardis Yousefi Talouki, Saeed Hesami Tackallou, Shahrokh Shojaei, Soheila Zamanlui Benisi and Vahabodin Goodarzi
    Citation: Biological Procedures Online 2023 25:9

    The Correction to this article has been published in Biological Procedures Online 2023 25:12

  43. Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor clinical prognosis. Rupture of the fibrous capsule (FC) is a very important clinical phenomenon in the invasion and metastasis of HCC. FC is ma...

    Authors: Quanwei Cui, Xuben Wang, Yongwei Zhang, Yiqing Shen and Yeben Qian
    Citation: Biological Procedures Online 2023 25:8
  44. RNA sequencing has become the gold standard for transcriptome analysis but has an inherent limitation of challenging quantification of low-abundant transcripts. In contrast to microarray technology, RNA sequen...

    Authors: Celine Everaert, Jasper Verwilt, Kimberly Verniers, Niels Vandamme, Alvaro Marcos Rubio, Jo Vandesompele and Pieter Mestdagh
    Citation: Biological Procedures Online 2023 25:7

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  • Citation Impact 2023
    Journal Impact Factor: 3.7
    5-year Journal Impact Factor: 4.6
    Source Normalized Impact per Paper (SNIP): 0.960
    SCImago Journal Rank (SJR): 1.048

    Speed 2023
    Submission to first editorial decision (median days): 8
    Submission to acceptance (median days): 76

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