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  1. Shoulder pain and disability from rotator cuff tears remain challenging clinical problem despite advancements in surgical techniques and materials. To advance our understanding of injury progression and develo...

    Authors: Shuting Huang, Ming Yik Tam, Wai Hon Caleb Ho, Hong Ki Wong, Meng Zhou, Chun Zeng, Denghui Xie, Dai Fei Elmer Ker, Samuel KK. Ling, Rocky S. Tuan and Dan Michelle Wang
    Citation: Biological Procedures Online 2024 26:31
    Content type: Methodology Published on:

  2. Astrocytes have recently gained attention as key players in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. Numerous differentiation protocols have been developed to study human ...

    Authors: Veronika JurĆ”kovĆ”, BalĆ”zs SzĆ©ky, Martina ZapletalovĆ”, Anita FehĆ©r, Melinda Zana, Shashank Pandey, Radek Kučera, Omar Å erĆ½, JiÅ™Ć­ Hudeček, AndrĆ”s DinnyĆ©s and Jan Lochman
    Citation: Biological Procedures Online 2024 26:30
    Content type: Research Published on:

  3. Pancreatic cancer is a devastating malignancy with a high mortality rate, poor prognosis, and limited treatment options. The tumor microenvironment (TME) plays a crucial role in tumor progression and therapy r...

    Authors: Bin Wang, Yue Pan, Yongjie Xie, Cong Wang, Yinli Yang, Haiyan Sun, Zhuchen Yan, Yameng Cui, Ling Li, Yaoyao Zhou, Weishuai Liu and Zhanyu Pan
    Citation: Biological Procedures Online 2024 26:29
    Content type: Research Published on:

  4. Breast cancer poses a significant health risk to women worldwide, with approximately 30% being diagnosed annually in the United States. The identification of cancerous mammary tissues from non-cancerous ones d...

    Authors: Ya Zhang, Zheng Li, Zhongqiang Li, Huaizhi Wang, Dinkar Regmi, Jian Zhang, Jiming Feng, Shaomian Yao and Jian Xu
    Citation: Biological Procedures Online 2024 26:28
    Content type: Research Published on:

  5. To explore the effects and mechanisms of the Xianhecao-Huanglian drug pair on autophagy-mediated intervention in acute inflammatory bowel disease (IBD) via the JAK2/STAT3 pathway. The study examined the underl...

    Authors: Yaping He, Xinling Shen and Haiyan Peng
    Citation: Biological Procedures Online 2024 26:27
    Content type: Research Published on:

  6. To investigate the survival outcome of ā€œradicalā€ GreenLight photoselective vaporization of bladder tumor (RPVBT) in conjunction with postoperative chemotherapy for patients with single, <ā€‰3 cm in diameter, T2 ...

    Authors: Zhihua Zhang, Yashen Wang, Fei Luo and Jian Li
    Citation: Biological Procedures Online 2024 26:26
    Content type: Research Published on:

  7. Oral cancers, specifically oral squamous cell carcinoma (OSCC), pose a significant global health challenge, with high incidence and mortality rates. Conventional treatments such as surgery, radiotherapy, and c...

    Authors: Kimia Sadat Kazemi, Parisa Kazemi, Hassan Mivehchi, Kamyar Nasiri, Seyed Saman Eshagh Hoseini, Seyedeh Tabasom Nejati, Parnian Pour Bahrami, Shayan Golestani and Mohsen Nabi Afjadi
    Citation: Biological Procedures Online 2024 26:25
    Content type: Review Published on:

  8. Breast cancer is the most common female malignancy worldwide. Ubiquitin-specific peptidase 53 (USP53) has been shown to exert cancer-suppressing functions in several solid tumors, but its role and the underlyi...

    Authors: Xiangchao Meng, Hongye Chen, Zhihui Tan, Weitao Yan, Yinfeng Liu, Ji Lv and Meng Han
    Citation: Biological Procedures Online 2024 26:24
    Content type: Research Published on:

  9. Mammalian oocytes accumulate more than ten thousand mRNAs, of which three to four thousand mRNAs are translationally repressed. The timings and sites of translational activation of these dormant mRNAs are cruc...

    Authors: Takahiro Sanada and Tomoya Kotani
    Citation: Biological Procedures Online 2024 26:23
    Content type: Methodology Published on:

  10. Peste des petits ruminants (PPRV), a highly contagious viral disease, causes significant economic losses concerning sheep and goats. Recently, PPR viruses (PPRVs), have adopted new hosts and lineage IV of PPRV...

    Authors: Tahira Kamal, Saeed-ul-Hassan Khan, Fariha Hassan, Amir-bin- Zahoor, Amman Ullah, S. Murtaza Hassan Andrabi, Ghulam Muhammad Ali, Tayyaba Afsar, Fohad Mabood Husain, Huma Shafique and Suhail Razak
    Citation: Biological Procedures Online 2024 26:22
    Content type: Research Published on:

  11. The role of tumor inflammatory microenvironment in the advancement of cancer, particularly prostate cancer, is widely acknowledged. ELL-associated factor 2 (EAF2), a tumor suppressor that has been identified i...

    Authors: Tianyu Cao, Qian Sun, Xiaoqin Shi, Xiuke Lin, Qingyuan Lin, Jinchao Zhu, Junhao Xu, Di Cui, Youwei Shi, Yifeng Jing and Wenhuan Guo
    Citation: Biological Procedures Online 2024 26:21
    Content type: Research Published on:

  12. Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, and affects large regions of Asia, Southwestern and Southeastern Europe, and Africa. CCHFV can produce symptoms, including no ...

    Authors: Khursheed Muzammil, Saba Rayyani, Ahmed Abbas Sahib, Omid Gholizadeh, Hayder Naji Sameer, Tareq Jwad Kazem, Haneen Badran Mohammed, Hesam Ghafouri Kalajahi, Rahadian Zainul and Saman Yasamineh
    Citation: Biological Procedures Online 2024 26:20
    Content type: Review Published on:

  13. Age-related macular degeneration (AMD) is a leading cause of blindness, affecting millions worldwide. Its complex pathogenesis involves a variety of risk factors, including lipid metabolism and inflammation. T...

    Authors: Wang Jingzhi and Xuehao Cui
    Citation: Biological Procedures Online 2024 26:19
    Content type: Research Published on:

  14. The lack of standardized protocols for isolating extracellular vesicles (EVs), especially from biobank-stored blood plasma, translates to limitations for the study of new biomarkers. This study examines whethe...

    Authors: Ana Torres, Lorena Bernardo, Carmen SƔnchez, Esperanza Morato, Jose Carlos Solana and Eugenia Carrillo
    Citation: Biological Procedures Online 2024 26:18
    Content type: Methodology Published on:

  15. Culex pipiens L. is a principal vector of zoonotic arboviruses in Europe, acting in both an amplification role in enzootic transmission between avian hosts and as a bridge vector between avian hosts and mammals. ...

    Authors: Laura Jones, Christopher Sanders, Marion England, Mary Cameron and Simon Carpenter
    Citation: Biological Procedures Online 2024 26:17
    Content type: Research Published on:

  16. It is necessary to develop advanced therapies utilizing natural ingredients with anti-inflammatory qualities in order to lessen the negative effects of chemotherapeutics.

    Authors: Dalia Medhat, Mona A. El-Bana, Ibrahim El-TantawyĀ El-Sayed, Abdullah A. S. Ahmed, Mehrez E. El-Naggar and Jihan Hussein
    Citation: Biological Procedures Online 2024 26:16
    Content type: Research Published on:

  17. Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. Exosomes can be derived from cancer cells as well as cellular components in tumor microenvironment....

    Authors: Yating Wu, Yue Cao, Li Chen, Xiaofeng Lai, Shenghang Zhang and Shuiliang Wang
    Citation: Biological Procedures Online 2024 26:15
    Content type: Review Published on:

  18. Extracellular vesicles (EVs) are nano-sized, membranous transporters of various active biomolecules with inflicting phenotypic capabilities, that are naturally secreted by almost all cells with a promising van...

    Authors: Nico G. Menjivar, Jaiden Oropallo, Samuel Gebremedhn, Luca A. Souza, Ahmed Gad, Christian M. Puttlitz and Dawit Tesfaye
    Citation: Biological Procedures Online 2024 26:14
    Content type: Review Published on:

  19. Pseudomyxoma peritonei (PMP) is a rare peritoneal mucinous carcinomatosis with largely unknown underlying molecular mechanisms. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is ...

    Authors: Antonio Romero-Ruiz, Melissa Granados-RodrĆ­guez, Florina I. Bura, Francisca Valenzuela-Molina, Blanca RufiĆ”n-AndĆŗjar, Ana MartĆ­nez-LĆ³pez, Lidia RodrĆ­guez-Ortiz, Rosa Ortega-Salas, MarĆ­a Torres-MartĆ­nez, Ana Moreno-Serrano, Justo CastaƱo, Carmen MichĆ”n, JosĆ© Alhama, Mari C. VĆ”zquez-Borrego and Ɓlvaro Arjona-SĆ”nchez
    Citation: Biological Procedures Online 2024 26:13
    Content type: Methodology Published on:

  20. Lung adenocarcinoma metastasizing to the brain results in a notable increase in patient mortality. The high incidence and its impact on survival presents a critical unmet need to develop an improved understand...

    Authors: Jianing Chen, Congli Hu, Hainan Yang, Li Wang, Xiangling Chu, Xin Yu, Shiji Zhang, Xuefei Li, Chao Zhao, Lei Cheng, Weiping Hong, Da Liu, Lei Wen and Chunxia Su
    Citation: Biological Procedures Online 2024 26:12
    Content type: Research Published on:

  21. The efficacy of oncolytic viruses (OV) in cancer treatment depends on their ability to successfully infect and destroy tumor cells. However, patientsā€™ tumors vary, and in the case of individual insensitivity t...

    Authors: Leslie Elsner, Lisanne Heimann, Anja Geisler, Babette Dieringer, Klaus-Peter Knoch, Luisa Hinze, Karin Klingel, Michel Solimena, Jens Kurreck and Henry Fechner
    Citation: Biological Procedures Online 2024 26:11
    Content type: Research Published on:

  22. Neoadjuvant therapy followed by surgery has become the standard of care for locally advanced esophageal squamous cell carcinoma (ESCC) and accurate pathological response assessment is critical to assess the th...

    Authors: Yichen Wang, Wenhua Zhang, Lijun Chen, Jun Xie, Xuebin Zheng, Yan Jin, Qiang Zheng, Qianqian Xue, Bin Li, Chuan He, Haiquan Chen and Yuan Li
    Citation: Biological Procedures Online 2024 26:10
    Content type: Research Published on:

  23. MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), original found in synthetic heroin, causes Parkinsonā€™s disease (PD) in human through its metabolite MPP+ by inhibiting complex I of mitochondrial respiratory c...

    Authors: Hongzhi Li, Jing Zhang, Yuqi Shen, Yifan Ye, Qingyou Jiang, Lan Chen, Bohao Sun, Zhuo Chen, Luxi Shen, Hezhi Fang, Jifeng Yang and Haihua Gu
    Citation: Biological Procedures Online 2024 26:9
    Content type: Research Published on:

  25. Osteoclasts are the tissue-specific macrophage population of the bone and unique in their bone-resorbing activity. Hence, they are fundamental for bone physiology in health and disease. However, efficient prot...

    Authors: Suganja Chandrabalan, Linh Dang, Uwe Hansen, Melanie Timmen, Corinna Wehmeyer, Richard Stange, Tim BeiƟbarth, Claudia Binder, Annalen Bleckmann and Kerstin Menck
    Citation: Biological Procedures Online 2024 26:7
    Content type: Methodology Published on:

  28. Metalā€“organic frameworks (MOFs) are porous materials with unique characteristics that make them well-suited for drug delivery and gene therapy applications. Among the MOFs, zeolitic imidazolate framework-8 (ZI...

    Authors: Marzieh Sameni, Parisa Moradbeigi, Sara Hosseini, Sayyed Mohammad Hossein Ghaderian, Vahid Jajarmi, Amir Hossein Miladipour, Hojat Basati, Maryam Abbasi and Mohammad Salehi
    Citation: Biological Procedures Online 2024 26:4
    Content type: Research Published on:

  29. Generating targeted mutant mice is a crucial technology in biomedical research. This study focuses on optimizing the CRISPR/Cas9 system uptake into sperm cells using the methyl Ī²-cyclodextrin-sperm-mediated ge...

    Authors: Parisa Moradbeigi, Sara Hosseini, Mohammad Salehi and Asghar Mogheiseh
    Citation: Biological Procedures Online 2024 26:3
    Content type: Research Published on:

    The Correction to this article has been published in Biological Procedures Online 2024 26:5

  30. Some of the most complex surgical interventions to treat trauma and cancer include the use of locoregional pedicled and free autologous tissue transfer flaps. While the techniques used for these reconstructive...

    Authors: Edita Aksamitiene, Ryan N. Heffelfinger, Jan B. Hoek and Edmund deAzevedo Pribitkin
    Citation: Biological Procedures Online 2024 26:2
    Content type: Methodology Published on:

  31. Gastric cancer (GC) is a common malignancy and a leading cause of cancer-related death with high morbidity and mortality. Methyl-CpG binding domain protein 3 (MBD3), a key epigenetic regulator, is abnormally e...

    Authors: Huizhi Wang, Jingyu Min, Yuntao Ding, Zhengyue Yu, Yujing Zhou, Shunyu Wang, Aihua Gong and Min Xu
    Citation: Biological Procedures Online 2024 26:1
    Content type: Research Published on:

  32. The action of mesenchymal stem cells (MSCs) is the subject of intense research in the field of regenerative medicine, including their potential use in companion animals, such as dogs. To ensure the safety of c...

    Authors: Emese Pekker, Katalin Priskin, Ɖva SzabĆ³-Kriston, Bernadett CsĆ”nyi, Orsolya BuzĆ”s-Bereczki, Lili AdorjĆ”n, ValĆ©ria Szukacsov, Lajos PintĆ©r, MiklĆ³s Rusvai, Paul Cooper, Endre Kiss-TĆ³th and Lajos Haracska
    Citation: Biological Procedures Online 2023 25:33
    Content type: Methodology Published on:

  33. Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cancers. Accumulating evidence suggests that inducing ferroptosis of tumor cells can inhibit...

    Authors: Xiaole Meng, Xiao Peng, Wanxin Ouyang, Hui Li, Risi Na, Wenting Zhou, Xuting You, Yuhuan Li, Xin Pu, Ke Zhang, Junjie Xia, Jie Wang, Guohong Zhuang, Huamei Tang and Zhihai Peng
    Citation: Biological Procedures Online 2023 25:32
    Content type: Research Published on:

  35. Ischemic stroke (IS) occurs when a blood vessel supplying the brain becomes obstructed, resulting in cerebral ischemia. This type of stroke accounts for approximately 87% of all strokes. Globally, IS leads to ...

    Authors: Yaowen Luo, Junkai Cheng, Yihao Fu, Min Zhang, Maorong Gou, Juan Li, Xiaobing Li, Jing Bai, Yuefei Zhou, Lei Zhang and Dakuan Gao
    Citation: Biological Procedures Online 2023 25:30
    Content type: Research Published on:

  36. Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propensity for metastasis. Patients diagnosed with localized primary cancer have higher survi...

    Authors: Bin Luo, Zujun Que, Xinyi Lu, Dan Qi, Zhi Qiao, Yun Yang, Fangfang Qian, Yi Jiang, Yan Li, Ronghu Ke, Xiaoyun Shen, Hua Xiao, Hegen Li, Erxi Wu and Jianhui Tian
    Citation: Biological Procedures Online 2023 25:29
    Content type: Research Published on:

  37. Extracellular vesicles (EVs) are nanoscale vesicles derived from cells that mediate intercellular communication by transporting bioactive molecules. They play significant roles in various physiological and pat...

    Authors: Li Wang, Xin Yu, Juan Zhou and Chunxia Su
    Citation: Biological Procedures Online 2023 25:28
    Content type: Review Published on:

  38. Arthropods transmit a wide range of pathogens of importance for the global health of humans, animals, and plants. One group of these arthropod vectors, Culicoides biting midges (Diptera: Ceratopogonidae), is the ...

    Authors: Marc GuimerĆ  Busquets, Faye V. Brown, Simon T. Carpenter, Karin E. Darpel and Christopher J. Sanders
    Citation: Biological Procedures Online 2023 25:27
    Content type: Research Published on:

  39. Astrocytes have recently gained attention as key contributors to the pathogenesis of neurodegenerative disorders including Parkinsonā€™s disease. To investigate human astrocytes in vitro, numerous differentiatio...

    Authors: Patrycja Mulica, Carmen Venegas, Zied Landoulsi, Katja Badanjak, Sylvie Delcambre, Maria Tziortziou, Soraya Hezzaz, Jenny Ghelfi, Semra Smajic, Jens Schwamborn, Rejko KrĆ¼ger, Paul Antony, Patrick May, Enrico Glaab, Anne GrĆ¼newald and Sandro L. Pereira
    Citation: Biological Procedures Online 2023 25:26
    Content type: Research Published on:

  40. Exosomes, a special subtype of extracellular vesicles derived from human cells, serve as vital mediators of intercellular communication by transporting diverse bioactive cargos, including proteins and enzymes....

    Authors: Christopher Olson, Pengyang Zhang, Joy Ku, Renceh Flojo, Darin Boyes and Biao Lu
    Citation: Biological Procedures Online 2023 25:25
    Content type: Research Published on:

  41. In view of the limited data on radiotherapy (RT) combined with immunotherapy in patients with extensive-stage small cell lung cancer (ES-SCLC), this study aimed to identify the immune activation effect on diff...

    Authors: Min Wu, Shihao Wu, Yuetong Chen, Liangchao Sun and Jundong Zhou
    Citation: Biological Procedures Online 2023 25:24
    Content type: Research Published on:

  43. The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the SARS-CoV-2 Spike protein via the receptor binding domain (RBD) to human angio...

    Authors: Shine Varghese Jancy, Santhik Subhasingh Lupitha, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Shijulal Nelson-Sathi, Roshny Prasad, Sara Jones, Sreekumar Easwaran, Pramod Darvin, Aswathy Sivasailam and Thankayyan Retnabai Santhoshkumar
    Citation: Biological Procedures Online 2023 25:22
    Content type: Research Published on:

  44. Clinical studies suggest that immune checkpoint inhibitor (ICI) monotherapy has limited benefits in non-small cell lung cancer (NSCLC) patients after epidermal growth factor receptor-tyrosine kinase inhibitor ...

    Authors: Juan Zhou, Xiangling Chu, Jing Zhao, Mengqing Xie, Jing Wu, Xin Yu, Yujia Fang, Yazhou Li, Xiyan Li and Chunxia Su
    Citation: Biological Procedures Online 2023 25:21
    Content type: Research Published on:

  45. The incidence and mortality of gastric cancer (GC) are high worldwide. Tumor stemness is a major contributor to tumorigenesis and development of GC, in which long non-coding RNAs (lncRNAs) are deeply involved....

    Authors: Xia Hu, Maoyuan Zhao, Shuangyuan Hu, Qingsong Liu, Wenhao Liao, Lina Wan, Feng Wei, Fangting Su, Yu Guo and Jinhao Zeng
    Citation: Biological Procedures Online 2023 25:20
    Content type: Research Published on:

  46. Resistance to HER2-targeted therapies, including the monoclonal antibody trastuzumab and tyrosine kinase inhibitor lapatinib, frequently occurs and currently represents a significant clinical challenge in the ...

    Authors: Hao Liu, Sanbao Ruan, Margaret E. Larsen, Congcong Tan, Bolin Liu and Hui Lyu
    Citation: Biological Procedures Online 2023 25:19
    Content type: Research Published on:

  47. One of the most prominent questions in the field of transgenesis is ā€˜Where in the genome to integrate a transgene?ā€™. Escape from epigenetic silencing and promoter shutdown of the transgene needs reliable genom...

    Authors: Nima Dehdilani, Lena Goshayeshi, Sara Yousefi Taemeh, Ahmad Reza Bahrami, Sylvie Rival Gervier, Bertrand Pain and Hesam Dehghani
    Citation: Biological Procedures Online 2023 25:18
    Content type: Research Published on:

  48. Deinococcus radiodurans is a robust bacterium that can withstand harsh environments that cause oxidative stress to macromolecules due to its cellular structure and physiological functions. Cells release extracell...

    Authors: Jeong Moo Han, Ha-Yeon Song, Jong-Hyun Jung, Sangyong Lim, Ho Seong Seo, Woo Sik Kim, Seung-Taik Lim and Eui-Baek Byun
    Citation: Biological Procedures Online 2023 25:17
    Content type: Research Published on:

  49. Immunotherapy is effective only in limited patients. It is urgent to discover a novel biomarker to predict immune cells infiltration status and immunotherapy response of different cancers. CLSPN has been repor...

    Authors: Yihong Chen, Haicheng Wen, Yin Li, Ying Han, Jun Tan, Cao Guo, Changjing Cai, Ping Liu, Yinghui Peng, Yihan Liu, Xinwen Wang, Shan Zeng, Ziyang Feng and Hong Shen
    Citation: Biological Procedures Online 2023 25:16
    Content type: Research Published on:

  50. Deep learning has been extensively used in digital histopathology. The purpose of this study was to test deep learning (DL) algorithms for predicting the vital status of whole-slide image (WSI) of uveal melano...

    Authors: Qi Wan, Xiang Ren, Ran Wei, Shali Yue, Lixiang Wang, Hongbo Yin, Jing Tang, Ming Zhang, Ke Ma and Ying-ping Deng
    Citation: Biological Procedures Online 2023 25:15
    Content type: Research Published on:
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  • Citation Impact 2023
    Journal Impact Factor: 3.7
    5-year Journal Impact Factor: 4.6
    Source Normalized Impact per Paper (SNIP): 0.960
    SCImago Journal Rank (SJR): 1.048

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Biological Procedures Online

ISSN: 1480-9222

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