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  1. The prognosis of wild-type BRAF cutaneous melanoma (WT Bf-CM) patients remains poor due to the lack of therapeutic options. However, few studies have investigated the factors contributing to the prognosis of W...

    Authors: Ruizheng Sun, Yaozhong Liu, Cheng Lei, Zhenwei Tang and Lixia Lu
    Citation: Biological Procedures Online 2022 24:7
  2. Metastatic Axillary Lymph Node (mALN) status is currently the most important prognostic factor in the management of primary breast cancer (BC). Thus, development of specimens which enable identification of new...

    Authors: Vesna Ivanović, Nasta Dedović-Tanić, Zorka Milovanović, Bratislav Stojiljković, Miroslav Demajo and Vesna Mandušić
    Citation: Biological Procedures Online 2022 24:6
  3. Numerous cancer-associated deaths are owing to a lack of effective diagnostic and therapeutic approaches. Microfluidic systems for analyzing a low volume of samples offer a precise, quick, and user-friendly te...

    Authors: Nasrin Bargahi, Samaneh Ghasemali, Samaneh Jahandar-Lashaki and Atefeh Nazari
    Citation: Biological Procedures Online 2022 24:5
  4. Objective Esophageal carcinoma (ESCA) is deadly cancer worldwide with unknown etiology. This study aimed to investigate the impact and mechanism of RAD6 on the development of Esophageal squamous cell carcinoma...

    Authors: Yu Deng, Yujiang Li, Tiantong Wu, Xuyuan Chen, Xiang Li, Kaican Cai and Xu Wu
    Citation: Biological Procedures Online 2022 24:4
  5. Flower color is one of the main characteristics of ornamental plants. Aurones are light yellow flavonoids produced in the petals of a limited number of plant species including snapdragon (Antirrhinum majus). As a...

    Authors: Amir Rajabi, Leila Fahmideh, Mojtaba Keykhasaber and Valiollah Ghasemi Omran
    Citation: Biological Procedures Online 2022 24:3
  6. Highly infectious illnesses caused by pathogens constitute severe threats to public health and lead to global economic loss. The use of robust and programmable clustered regularly interspaced short palindromic...

    Authors: Xiaolong Liu, Mubashir Hussain, Jianguo Dai, Yonghong Li, Lijun Zhang, Jian Yang, Zeeshan Ali, Nongyue He and Yongjun Tang
    Citation: Biological Procedures Online 2022 24:2
  7. Due to the importance of using cost-effective methods for therapeutic purposes, the function of probiotics as safe microorganisms and the study of their relevant functional mechanisms have recently been in the...

    Authors: Nahid Javanshir, Golsa Nayeb Ghanbar Hosseini, Mahdieh Sadeghi, Ramtin Esmaeili, Fateme Satarikia, Gholamreza Ahmadian and Najaf Allahyari
    Citation: Biological Procedures Online 2021 23:23
  8. Heregulin is a ligand for the protooncogene product ErbB/HER that acts as  a key mitogenic factor for human Schwann cells (hSCs). Heregulin is required for sustained hSC growth in vitro but must be thoroughly ...

    Authors: Paula V. Monje, Ketty Bacallao, Gabriela I. Aparicio and Anil Lalwani
    Citation: Biological Procedures Online 2021 23:22
  9. Because of the high frequency of chronic edema formation in the current “aged” society, analyses and detailed observation of post-surgical edema are getting more required. Post-surgical examination of the dyna...

    Authors: Shinji Kumegawa, Gen Yamada, Daiki Hashimoto, Tsuyoshi Hirashima, Mizuki Kajimoto, Kyoichi Isono, Kota Fujimoto, Kentaro Suzuki, Kazuhisa Uemura, Masatsugu Ema and Shinichi Asamura
    Citation: Biological Procedures Online 2021 23:21
  10. Auto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthriti...

    Authors: Zahra Payandeh, Abbas Pirpour Tazehkand, Ali Azargoonjahromi, Faezeh Almasi and Armina Alagheband Bahrami
    Citation: Biological Procedures Online 2021 23:20
  11. The detection of SARS-CoV-2 using qRT-PCR with the pooling of samples can reduce workload and costs especially when the prevalence rate of COVID-19 in a population is low.

    Authors: Imene Handous, Naila Hannachi, Manel Marzouk, Olfa Hazgui, Nissaf Bouafif Ep Ben Alaya and Jalel Boukadida
    Citation: Biological Procedures Online 2021 23:19
  12. In the area of oral and maxillofacial surgery, regenerative endodontics aims to present alternative options to conventional treatment strategies. With continuous advances in regenerative medicine, the source o...

    Authors: Benson Koh, Nadiah Sulaiman, Sharifah Nursyazwani Shahirah Wan Ismadi, Roszalina Ramli, Siti Salmiah Mohd Yunus, Ruszymah Bt Hj Idrus, Shahrul Hisham Zainal Ariffin, Rohaya Megat Abdul Wahab and Muhammad Dain Yazid
    Citation: Biological Procedures Online 2021 23:18
  13. The Interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with Angiotensin converting enzyme 2 (ACE2) on the host cells is a crucial step for the viral entry and infect...

    Authors: Yuning Shang, Feixiang Chen, Shasha Li, Lijuan Song, Yunzhen Gao, Xinhua Yu and Junfeng Zheng
    Citation: Biological Procedures Online 2021 23:16
  14. Colorectal cancer (CRC) is a universal heterogeneous disease that is characterized by genetic and epigenetic alterations. Immunotherapy using monoclonal antibodies (mAb) and cancer vaccines are substitute stra...

    Authors: Ali Azadi, Alireza Golchini, Sina Delazar, Fatemeh Abarghooi Kahaki, Seyed Mohsen Dehnavi, Zahra Payandeh and Shirin Eyvazi
    Citation: Biological Procedures Online 2021 23:13
  15. Expression of stemness factors, such as octamer-binding transcription factor 3/4 (OCT3/4), sex determining region Y-box 2 (SOX2), and alkaline phosphatase (ALP) in human deciduous tooth-derived dental pulp cells ...

    Authors: Emi Inada, Issei Saitoh, Naoko Kubota, Yoko Iwase, Yuki Kiyokawa, Hirofumi Noguchi, Youichi Yamasaki and Masahiro Sato
    Citation: Biological Procedures Online 2021 23:12
  16. Although retinitis pigmentosa (RP) is most frequently studied in mouse models, rats, rabbits, and pigs are also used as animal models of RP. However, no studies have reported postnatal photoreceptor cell loss ...

    Authors: Chisato Inoue, Tamaki Takeuchi, Akira Shiota, Mineo Kondo and Yuji Nshizawa
    Citation: Biological Procedures Online 2021 23:11
  17. We investigated nasopharyngeal microbial community structure in COVID-19-positive and -negative patients. High-throughput 16S ribosomal RNA gene amplicon sequencing revealed significant microbial community str...

    Authors: Phillip A. Engen, Ankur Naqib, Cheryl Jennings, Stefan J. Green, Alan Landay, Ali Keshavarzian and Robin M. Voigt
    Citation: Biological Procedures Online 2021 23:10
  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang and Charles Lee
    Citation: Biological Procedures Online 2021 23:9

    The original article was published in Biological Procedures Online 2021 23:1

  19. Insufficient insulin secretion is a key component of both type 1 and type 2 diabetes. Since insulin is released by the islets of Langerhans, obtaining viable and functional islets is critical for research and ...

    Authors: Kathryn L. Corbin, Hannah L. West, Samantha Brodsky, Nicholas B. Whitticar, William J. Koch and Craig S. Nunemaker
    Citation: Biological Procedures Online 2021 23:7
  20. The proteostasis network includes all the factors that control the function of proteins in their native state and minimize their non-functional or harmful reactions. The molecular chaperones, the important med...

    Authors: Fateme Khomari, Mohsen Nabi-Afjadi, Sahar Yarahmadi, Hanie Eskandari and Elham Bahreini
    Citation: Biological Procedures Online 2021 23:8
  21. In the present study, two distinct PCR methods were used for the quantification of genetic material and their results were compared: real-time-PCR (qPCR; relative quantification) and droplet digital PCR (ddPCR...

    Authors: Kevin Kuhlmann, Melanie Cieselski and Julia Schumann
    Citation: Biological Procedures Online 2021 23:6
  22. COVID-19, a pandemic of the 21st century caused by novel coronavirus SARS-CoV-2 was originated from China and shallowed world economy and human resource. The medical cures via herbal treatments, antiviral drug...

    Authors: Jyoti Choudhary, Shrivardhan Dheeman, Vipin Sharma, Prashant Katiyar, Santosh Kumar Karn, Manoj Kumar Sarangi, Ankit Kumar Chauhan, Gaurav Verma and Nitin Baliyan
    Citation: Biological Procedures Online 2021 23:5
  23. Angiotensin-converting enzyme (ACE) plays a major role in blood pressure regulation and cardiovascular homeostasis. The wide distribution and multifunctional properties of ACE suggest it’s involvement in vario...

    Authors: Xue-min Yang, Jian-ping Liang, Xiao-juan Huang, Xiang-rong Wang, Yang Sun, Chen Dong, Ya-li Cui and Wen-li Hui
    Citation: Biological Procedures Online 2021 23:2
  24. Gastric cancer metastasis is a highly fatal disease with a five-year survival rate of less than 5%. One major obstacle in studying gastric cancer metastasis is the lack of faithful models available. The cancer...

    Authors: Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang and Charles Lee
    Citation: Biological Procedures Online 2021 23:1

    The Correction to this article has been published in Biological Procedures Online 2021 23:9

  25. Ocriplasmin (Jetrea) is using for the treatment of symptomatic vitreomacular adhesion. This enzyme undergoes rapid inactivation and limited activity duration as a result of its autolytic nature after injection...

    Authors: Roghayyeh Baghban, Safar Farajnia, Younes Ghasemi, Reyhaneh Hoseinpoor, Azam Safary, Mojtaba Mortazavi and Nosratollah Zarghami
    Citation: Biological Procedures Online 2020 22:25
  26. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Somayeh Jolany vangah, Camellia Katalani, Hannah A. Boone, Abbas Hajizade, Adna Sijercic and Gholamreza Ahmadian
    Citation: Biological Procedures Online 2020 22:24

    The original article was published in Biological Procedures Online 2020 22:22

  27. DNA repair pathways, cell cycle arrest checkpoints, and cell death induction are present in cells to process DNA damage and prevent genomic instability caused by various extrinsic and intrinsic ionizing factor...

    Authors: Fatemeh Sadeghi, Marzieh Asgari, Mojdeh Matloubi, Maral Ranjbar, Nahid Karkhaneh Yousefi, Tahereh Azari and Majid Zaki-Dizaji
    Citation: Biological Procedures Online 2020 22:23
  28. Interest in CRISPR technology, an instrumental component of prokaryotic adaptive immunity which enables prokaryotes to detect any foreign DNA and then destroy it, has gained popularity among members of the sci...

    Authors: Somayeh Jolany vangah, Camellia Katalani, Hannah A. Boone, Abbas Hajizade, Adna Sijercic and Gholamreza Ahmadian
    Citation: Biological Procedures Online 2020 22:22

    The Correction to this article has been published in Biological Procedures Online 2020 22:24

  29. Currently there are no effective anti-viral drugs for SARS-CoV-2, so the primary line of defense is to detect infected cases as soon as possible. The high rate of contagion for this virus and the highly nonspe...

    Authors: Elena Ekrami, Mahdi Pouresmaieli, Fatemeh Barati, Sahar Asghari, Farzad Ramezani Ziarani, Parvin Shariati and Matin Mamoudifard
    Citation: Biological Procedures Online 2020 22:21
  30. Ligamentum flavum hypertrophy (LFH) is among the most crucial factors in degenerative lumbar spinal stenosis, which can cause back pain, lower extremity pain, cauda equina syndrome and neurogenic claudication....

    Authors: Cheng-Li Lin, Yi-Ting Kuo, Che-Hao Tsao, Yan-Jye Shyong, Shu-Hsien Shih and Ting-Yuan Tu
    Citation: Biological Procedures Online 2020 22:20
  31. In December 2019, a novel coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or (2019-nCoV) with unknown origin spread in Hubei province of China. The epidemic disease caused by SA...

    Authors: Hanie Esakandari, Mohsen Nabi-Afjadi, Javad Fakkari-Afjadi, Navid Farahmandian, Seyed-Mohsen Miresmaeili and Elham Bahreini
    Citation: Biological Procedures Online 2020 22:19
  32. Improper regulation of apoptosis has been postulated as one of the main factors that contributes to the etiology and/or progression of several prevalent diseases, including ischemic stroke and neurodegenerativ...

    Authors: Gemma Serrano-Heras, Inmaculada Díaz-Maroto, Beatriz Castro-Robles, Blanca Carrión, Ana B. Perona-Moratalla, Julia Gracia, Sandra Arteaga, Francisco Hernández-Fernández, Jorge García-García, Oscar Ayo-Martín and Tomás Segura
    Citation: Biological Procedures Online 2020 22:17
  33. We analyzed the bacterial communities of the nasopharynx in 40 SARS-CoV-2 infected and uninfected patients. All infected patients had a mild COVID-19 disease. We did not find statistically significant differen...

    Authors: Flavio De Maio, Brunella Posteraro, Francesca Romana Ponziani, Paola Cattani, Antonio Gasbarrini and Maurizio Sanguinetti
    Citation: Biological Procedures Online 2020 22:18
  34. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 19 (COVID-19) that was emerged as a new member of coronaviruses since December 2019 in Wuhan, China an...

    Authors: Reza Zolfaghari Emameh, Hassan Nosrati, Mahyar Eftekhari, Reza Falak and Majid Khoshmirsafa
    Citation: Biological Procedures Online 2020 22:16
  35. COVID-19 disease with a high rate of contagious and highly nonspecific symptoms, is an infectious disease caused by a newly discovered coronavirus. Most people who fall sick with COVID-19 will experience mild ...

    Authors: Fatemeh Barati, Mahdi Pouresmaieli, Elena Ekrami, Sahar Asghari, Farzad Ramezani Ziarani and Matin Mamoudifard
    Citation: Biological Procedures Online 2020 22:15
  36. The generation of point mutations is a major tool for evaluating the roles of specific nucleotides or amino acids within the regulatory or functional landscape. However, examination of these mutations in vivo ...

    Authors: Tgst Levi, Anna Sloutskin, Rachel Kalifa, Tamar Juven-Gershon and Offer Gerlitz
    Citation: Biological Procedures Online 2020 22:14
  37. Three-dimensional imaging modalities for optically dense connective tissues such as tendons are limited and typically have a single imaging methodological endpoint. Here, we have developed a bimodal procedure ...

    Authors: Neil Marr, Mark Hopkinson, Andrew P. Hibbert, Andrew A. Pitsillides and Chavaunne T. Thorpe
    Citation: Biological Procedures Online 2020 22:13
  38. Circulating small extracellular vesicles (sEVs) and its associated proteins are of great interest in the early detection of many diseases. However, there is no gold standard for plasma sEVs isolation, especial...

    Authors: Rui Wei, Libo Zhao, Guanyi Kong, Xiang Liu, Shengtao Zhu, Shutian Zhang and Li Min
    Citation: Biological Procedures Online 2020 22:12
  39. Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears with common symptoms including fever, dry cough, and fatigue, as well as some less common s...

    Authors: Reza Zolfaghari Emameh, Reza Falak and Elham Bahreini
    Citation: Biological Procedures Online 2020 22:11
  40. Circular RNAs (circRNAs) have emerged as a universal novel class of eukaryotic non-coding RNA (ncRNA) molecules and are becoming a new research hotspot in RNA biology. They form a covalent loop without 5′ cap ...

    Authors: Peerzada Tajamul Mumtaz, Qamar Taban, Mashooq Ahmad Dar, Shabir Mir, Zulfkar ul Haq, Sajad Majeed Zargar, Riaz Ahmad Shah and Syed Mudasir Ahmad
    Citation: Biological Procedures Online 2020 22:10
  41. The BioBrick construction as an approach in synthetic biology provides the ability to assemble various gene fragments. To date, different BioBrick strategies have been exploited for assembly and cloning of a v...

    Authors: Amin Tavassoli, Safoura Soleymani, Alireza Haghparast, Gholamreza Hashemi Tabar, Mohammad Reza Bassami and Hesam Dehghani
    Citation: Biological Procedures Online 2020 22:9
  42. Coronavirus disease 2019 (COVID-19) is an emerging zoonotic viral infection, which was started in Wuhan, China, in December 2019 and transmitted to other countries worldwide as a pandemic outbreak. Iran is one...

    Authors: Reza Zolfaghari Emameh, Hassan Nosrati and Ramezan Ali Taheri
    Citation: Biological Procedures Online 2020 22:8
  43. The human Caco-2 cell line is a common in vitro model of the intestinal epithelial barrier. As the intestine is a major interface in cholesterol turnover and represents a non-biliary pathway for cholesterol ex...

    Authors: Verena Hiebl, Daniel Schachner, Angela Ladurner, Elke H. Heiss, Herbert Stangl and Verena M. Dirsch
    Citation: Biological Procedures Online 2020 22:7

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