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  1. Astrocytes have recently gained attention as key contributors to the pathogenesis of neurodegenerative disorders including Parkinson’s disease. To investigate human astrocytes in vitro, numerous differentiatio...

    Authors: Patrycja Mulica, Carmen Venegas, Zied Landoulsi, Katja Badanjak, Sylvie Delcambre, Maria Tziortziou, Soraya Hezzaz, Jenny Ghelfi, Semra Smajic, Jens Schwamborn, Rejko Krüger, Paul Antony, Patrick May, Enrico Glaab, Anne Grünewald and Sandro L. Pereira
    Citation: Biological Procedures Online 2023 25:26
  2. Exosomes, a special subtype of extracellular vesicles derived from human cells, serve as vital mediators of intercellular communication by transporting diverse bioactive cargos, including proteins and enzymes....

    Authors: Christopher Olson, Pengyang Zhang, Joy Ku, Renceh Flojo, Darin Boyes and Biao Lu
    Citation: Biological Procedures Online 2023 25:25
  3. In view of the limited data on radiotherapy (RT) combined with immunotherapy in patients with extensive-stage small cell lung cancer (ES-SCLC), this study aimed to identify the immune activation effect on diff...

    Authors: Min Wu, Shihao Wu, Yuetong Chen, Liangchao Sun and Jundong Zhou
    Citation: Biological Procedures Online 2023 25:24
  4. The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the SARS-CoV-2 Spike protein via the receptor binding domain (RBD) to human angio...

    Authors: Shine Varghese Jancy, Santhik Subhasingh Lupitha, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Shijulal Nelson-Sathi, Roshny Prasad, Sara Jones, Sreekumar Easwaran, Pramod Darvin, Aswathy Sivasailam and Thankayyan Retnabai Santhoshkumar
    Citation: Biological Procedures Online 2023 25:22
  5. Clinical studies suggest that immune checkpoint inhibitor (ICI) monotherapy has limited benefits in non-small cell lung cancer (NSCLC) patients after epidermal growth factor receptor-tyrosine kinase inhibitor ...

    Authors: Juan Zhou, Xiangling Chu, Jing Zhao, Mengqing Xie, Jing Wu, Xin Yu, Yujia Fang, Yazhou Li, Xiyan Li and Chunxia Su
    Citation: Biological Procedures Online 2023 25:21
  6. The incidence and mortality of gastric cancer (GC) are high worldwide. Tumor stemness is a major contributor to tumorigenesis and development of GC, in which long non-coding RNAs (lncRNAs) are deeply involved....

    Authors: Xia Hu, Maoyuan Zhao, Shuangyuan Hu, Qingsong Liu, Wenhao Liao, Lina Wan, Feng Wei, Fangting Su, Yu Guo and Jinhao Zeng
    Citation: Biological Procedures Online 2023 25:20
  7. Resistance to HER2-targeted therapies, including the monoclonal antibody trastuzumab and tyrosine kinase inhibitor lapatinib, frequently occurs and currently represents a significant clinical challenge in the ...

    Authors: Hao Liu, Sanbao Ruan, Margaret E. Larsen, Congcong Tan, Bolin Liu and Hui Lyu
    Citation: Biological Procedures Online 2023 25:19
  8. One of the most prominent questions in the field of transgenesis is ‘Where in the genome to integrate a transgene?’. Escape from epigenetic silencing and promoter shutdown of the transgene needs reliable genom...

    Authors: Nima Dehdilani, Lena Goshayeshi, Sara Yousefi Taemeh, Ahmad Reza Bahrami, Sylvie Rival Gervier, Bertrand Pain and Hesam Dehghani
    Citation: Biological Procedures Online 2023 25:18
  9. Deinococcus radiodurans is a robust bacterium that can withstand harsh environments that cause oxidative stress to macromolecules due to its cellular structure and physiological functions. Cells release extracell...

    Authors: Jeong Moo Han, Ha-Yeon Song, Jong-Hyun Jung, Sangyong Lim, Ho Seong Seo, Woo Sik Kim, Seung-Taik Lim and Eui-Baek Byun
    Citation: Biological Procedures Online 2023 25:17
  10. Immunotherapy is effective only in limited patients. It is urgent to discover a novel biomarker to predict immune cells infiltration status and immunotherapy response of different cancers. CLSPN has been repor...

    Authors: Yihong Chen, Haicheng Wen, Yin Li, Ying Han, Jun Tan, Cao Guo, Changjing Cai, Ping Liu, Yinghui Peng, Yihan Liu, Xinwen Wang, Shan Zeng, Ziyang Feng and Hong Shen
    Citation: Biological Procedures Online 2023 25:16
  11. Deep learning has been extensively used in digital histopathology. The purpose of this study was to test deep learning (DL) algorithms for predicting the vital status of whole-slide image (WSI) of uveal melano...

    Authors: Qi Wan, Xiang Ren, Ran Wei, Shali Yue, Lixiang Wang, Hongbo Yin, Jing Tang, Ming Zhang, Ke Ma and Ying-ping Deng
    Citation: Biological Procedures Online 2023 25:15
  12. The treatment efficacy of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) varies widely between individuals. The aim of this study was to identify subtype landscapes and responser rel...

    Authors: Bufu Tang, Yajie Wang, Jinyu Zhu, Jingjing Song, Shiji Fang, Qiaoyou Weng, Yang Yang, Jianfei Tu, Zhongwei Zhao, Minjiang Chen, Min Xu, Weiqian Chen and Jiansong Ji
    Citation: Biological Procedures Online 2023 25:13
  13. Authors: Pardis Yousefi Talouki, Saeed Hesami Tackallou, Shahrokh Shojaei, Soheila Zamanlui Benisi and Vahabodin Goodarzi
    Citation: Biological Procedures Online 2023 25:12

    The original article was published in Biological Procedures Online 2023 25:9

  14. Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children, which is highly prone to bone marrow (BM) metastasis. BM can monitor early signs of mild disease and metastasis. Existing b...

    Authors: Chiyi Jiang, Yeran Yang, Sidou He, Zhixia Yue, Tianyu Xing, Ping Chu, Wenfa Yang, Hui Chen, Xiaoxi Zhao, Yongbo Yu, Xuan Zhang, Yan Su, Yongli Guo and Xiaoli Ma
    Citation: Biological Procedures Online 2023 25:11
  15. Sepsis-related acute kidney injury (AKI) is an inflammatory disease associated with extremely high mortality and health burden. This study explored the possibility of exosomes secreted by adipose-derived mesen...

    Authors: Wei Liu, Chenghuan Hu, Buyao Zhang, Mingxia Li, Fuxing Deng and Shuangping Zhao
    Citation: Biological Procedures Online 2023 25:10
  16. Tissue engineering for cartilage regeneration has made great advances in recent years, although there are still challenges to overcome. This study aimed to evaluate the chondrogenic differentiation of human ad...

    Authors: Pardis Yousefi Talouki, Saeed Hesami Tackallou, Shahrokh Shojaei, Soheila Zamanlui Benisi and Vahabodin Goodarzi
    Citation: Biological Procedures Online 2023 25:9

    The Correction to this article has been published in Biological Procedures Online 2023 25:12

  17. Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor clinical prognosis. Rupture of the fibrous capsule (FC) is a very important clinical phenomenon in the invasion and metastasis of HCC. FC is ma...

    Authors: Quanwei Cui, Xuben Wang, Yongwei Zhang, Yiqing Shen and Yeben Qian
    Citation: Biological Procedures Online 2023 25:8
  18. RNA sequencing has become the gold standard for transcriptome analysis but has an inherent limitation of challenging quantification of low-abundant transcripts. In contrast to microarray technology, RNA sequen...

    Authors: Celine Everaert, Jasper Verwilt, Kimberly Verniers, Niels Vandamme, Alvaro Marcos Rubio, Jo Vandesompele and Pieter Mestdagh
    Citation: Biological Procedures Online 2023 25:7
  19. YTHDF2 is one of important readers of N6-methyladenosine (m6A) modification on RNA. Growing evidence implicates that YTHDF2 takes an indispensable part in the regulation of tumorigenesis and metastasis in differe...

    Authors: Ying Zhou, Kailing Fan, Ning Dou, Li Li, Jialin Wang, Jingde Chen, Yandong Li and Yong Gao
    Citation: Biological Procedures Online 2023 25:6
  20. Lung cancer is the most common cause of cancer-related death globally. There are several reasons for this high mortality rate, including metastasis to multiple organs, especially the brain. Exosomes play a piv...

    Authors: Lingyun Ye, Yinfei Wu, Juan Zhou, Mengqing Xie, Zhemin Zhang and Chunxia Su
    Citation: Biological Procedures Online 2023 25:5
  21. Intraneuronal tau aggregation is the major pathological hallmark of neurodegenerative tauopathies. It is now generally acknowledged that tau aggregation also affects astrocytes in a cell non-autonomous manner....

    Authors: Kevin L. Batenburg, Claudia Sestito, Paulien Cornelissen-Steijger, Jan R. T. van Weering, Leo S. Price, Vivi M. Heine and Wiep Scheper
    Citation: Biological Procedures Online 2023 25:4
  22. Periodontal regeneration, treatment of periodontal-related diseases and improving the function of implants are global therapeutic challenges. The differentiation of human stem cells from apical papilla into ce...

    Authors: Morvarid Ebadi, Amirfarhang Miresmaeili, Sarah Rajabi, Shahrokh Shojaei and Sareh Farhadi
    Citation: Biological Procedures Online 2023 25:2

    The Correction to this article has been published in Biological Procedures Online 2023 25:14

  23. P2RX7 is a purinergic receptor with pleiotropic activities that is activated by high levels of extracellular ATP that are found in inflamed tissues. P2RX7 has immunomodulatory and anti-tumor proprieties and is...

    Authors: Serena Janho dit Hreich, Thierry Juhel, Paul Hofman and Valérie Vouret-Craviari
    Citation: Biological Procedures Online 2023 25:1
  24. Sjogren’s syndrome (SS) is an autoimmune disorder characterized by the destruction of exocrine glands, resulting in dry mouth and eyes. Currently, there is no effective treatment for SS, and the mechanisms ass...

    Authors: Bo Chen, Jiannan Zhou, Tianjiao Mao, Tingting Cao, Shilin Hu, Wenqi Zhang, Xueyang Li, Xiuni Qin, Xintong Liu, Nobumoto Watanabe and Jiang Li
    Citation: Biological Procedures Online 2022 24:26
  25. Desmoid tumor (DT), also known as desmoid-type fibromatosis (DTF) or aggressive fibromatosis (AF) is a rare mesenchymal tumor affecting both children and adults. It is non-metastasis but infiltrative, growing ...

    Authors: Bo Ning, Peng Huang, Lining Zhu, Zhijie Ma, Xiaoli Chen, Haojun Xu, Ruixue Ma, Chengyun Yao, Pengfei Zheng, Tian Xia and Hongping Xia
    Citation: Biological Procedures Online 2022 24:25
  26. Cellular senescence is a tumor suppressive response in which the cell cycle is in a state of permanent arrest and can inhibit tumor cell proliferation. In recent years, induction of cellular senescence has bee...

    Authors: Liang Sun, Zitao Liu, Ke Ning, Zhipeng Wu, Zhendong Chen, Zhengyi Wu and Xiangbao Yin
    Citation: Biological Procedures Online 2022 24:24
  27. The chloroplast is a semi-autonomous organelle having its own genome and corresponding proteome. Although chloroplast genomes have been reported, no reports exist on their corresponding proteomes. Therefore, a...

    Authors: Tapan Kumar Mohanta, Yugal Kishore Mohanta and Ahmed Al-Harrasi
    Citation: Biological Procedures Online 2022 24:23
  28. Hepatocellular carcinoma (HCC) belongs to a representative lethality gastrointestinal malignancy, and comprehensive management of HCC remains intractable at present on account of its invasive biological featur...

    Authors: Xiangyu Li, Kai Zhao, Yun Lu, Jianming Wang and Wei Yao
    Citation: Biological Procedures Online 2022 24:22
  29. A variety of studies have connected circadian rhythm to the initiation and progression of hepatocellular carcinoma (HCC). The purpose of this study was to figure out about the circadian genes' profile characte...

    Authors: Mengqi Zhu, Jianping Zhang, Saiyan Bian, Xue Zhang, Yiping Shen, Zhiyu Ni, Shiyu Xu, Chun Cheng and Wenjie Zheng
    Citation: Biological Procedures Online 2022 24:21
  30. The emergence of antibiotic-resistant pathogens has threatened not only our ability to deal with common infectious diseases but also the management of life-threatening complications. Antimicrobial resistance (...

    Authors: Bashar Haruna Gulumbe, Usman Abubakar Haruna, Joseph Almazan, Ibrahim Haruna Ibrahim, Abdullahi Adamu Faggo and Abbas Yusuf Bazata
    Citation: Biological Procedures Online 2022 24:19
  31. Advances in next-generation sequencing technologies have accelerated the momentum of metagenomic studies, which is increasing yearly. The metagenomics field is one of the versatile applications in microbiology...

    Authors: Gauri S. Navgire, Neha Goel, Gifty Sawhney, Mohit Sharma, Prashant Kaushik, Yugal Kishore Mohanta, Tapan Kumar Mohanta and Ahmed Al-Harrasi
    Citation: Biological Procedures Online 2022 24:18
  32. Phenotyping sputum-resident leukocytes and evaluating their functional status are essential analyses for exploring the cellular basis of pathological processes in the lungs, and flow cytometry is widely recogn...

    Authors: Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Sara Fernández, María Concepción Álvarez, Antonio Oliver and Roberto de la Rica
    Citation: Biological Procedures Online 2022 24:17
  33. Micro RNA of Marsupenaeus japonicas has been known to promote apoptosis of tumor cells. However, the detailed mechanisms are not well understood.

    Authors: Hyueyun Kim, Ji Ha Choi, Chang Mo Moon, Jihee Lee Kang, Minna Woo and Minsuk Kim
    Citation: Biological Procedures Online 2022 24:16
  34. Angiotensin-converting enzyme 2 (ACE2) is known as a tumor suppressor and lowly expressed in most cancers. The expression pattern and role of ACE2 in breast cancer (BC) have not been deeply elucidated.

    Authors: Jie Mei, Yun Cai, Rui Xu, Xinqian Yu, Xu Han, Miaomiao Weng, Lingyan Chen, Tao Ma, Tianshu Gao, Fei Gao, Tiansong Xia, Yichao Zhu and Yan Zhang
    Citation: Biological Procedures Online 2022 24:15
  35. Emerging evidence have revealed that circRNAs exert important biological effects in the development and progression of various diseases, including cancer. Our study aimed to elaborated the biological effects o...

    Authors: Xu Zhang, Wenwen Chen, Dan Guo, Yarui Li, Yan Zhao, Mudan Ren, Guifang Lu, Xinlan Lu and Shuixiang He
    Citation: Biological Procedures Online 2022 24:14
  36. Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Single-cell transcriptome sequencing (scRNA-seq) can provide accurate gene expression data for individual cells. In this ...

    Authors: Ziyang Di, Sicheng Zhou, Gaoran Xu, Lian Ren, Chengxin Li, Zheyu Ding, Kaixin Huang, Leilei Liang and Yihang Yuan
    Citation: Biological Procedures Online 2022 24:13
  37. Bladder cancer (BCa) is a fatal form of cancer worldwide associated with a poor prognosis. Identifying novel drivers of growth and metastasis hold therapeutic potential for the disease. Transport homeostasis b...

    Authors: Xiangui Meng, Weiquan Li, Hongwei Yuan, Wei Dong, Wen Xiao and Xiaoping Zhang
    Citation: Biological Procedures Online 2022 24:12
  38. Liver inflammation is a multistep process that is linked with cell membrane fatty acids composition. The effectiveness of eicosapentaenoic acid (EPA) undergoes an irreversible change during processing due to t...

    Authors: Jihan Hussein, Mona A. El-Bana, Zakaria El-kHayat, Mehrez E. El-Naggar, Abdel Razik Farrag and Dalia Medhat
    Citation: Biological Procedures Online 2022 24:11
  39. The effects of Otubain-2 (OTUB2) on the proliferation, invasion, and migration of esophageal squamous cell carcinoma (ESCC) were investigated by interfering with OTUB2 expression.

    Authors: Li Liu, Hu Cheng, Min Ji, Liping Su, Ziyang Lu, Xiayun Hu, Yaling Guan, Jinling Xiao, Lijuan Ma, Wei Zhang and Hongwei Pu
    Citation: Biological Procedures Online 2022 24:10
  40. Long non-coding RNAs (lncRNA) have been implicated in a hand of studies that supported an involvement and co-operation in Uterine Corpus Endometrial Carcinoma (UCEC). Enhancer RNAs (eRNA), a functional subtype...

    Authors: Jinhui Liu, Jian Yin, Yuanyuan Wang, Lixin Cai, Rui Geng, Mulong Du, Zihang Zhong, Senmiao Ni, Xiaohao Huang, Hao Yu and Jianling Bai
    Citation: Biological Procedures Online 2022 24:9
  41. The growing detection of long noncoding RNAs (lncRNAs) required the application of functional approaches in order to provide absolutely precise, conducive, and reliable processed information along with effecti...

    Authors: Narjes Azadbakht, Abbas Doosti and Mohammad-Saeid Jami
    Citation: Biological Procedures Online 2022 24:8
  42. The prognosis of wild-type BRAF cutaneous melanoma (WT Bf-CM) patients remains poor due to the lack of therapeutic options. However, few studies have investigated the factors contributing to the prognosis of W...

    Authors: Ruizheng Sun, Yaozhong Liu, Cheng Lei, Zhenwei Tang and Lixia Lu
    Citation: Biological Procedures Online 2022 24:7
  43. Metastatic Axillary Lymph Node (mALN) status is currently the most important prognostic factor in the management of primary breast cancer (BC). Thus, development of specimens which enable identification of new...

    Authors: Vesna Ivanović, Nasta Dedović-Tanić, Zorka Milovanović, Bratislav Stojiljković, Miroslav Demajo and Vesna Mandušić
    Citation: Biological Procedures Online 2022 24:6
  44. Numerous cancer-associated deaths are owing to a lack of effective diagnostic and therapeutic approaches. Microfluidic systems for analyzing a low volume of samples offer a precise, quick, and user-friendly te...

    Authors: Nasrin Bargahi, Samaneh Ghasemali, Samaneh Jahandar-Lashaki and Atefeh Nazari
    Citation: Biological Procedures Online 2022 24:5
  45. Objective Esophageal carcinoma (ESCA) is deadly cancer worldwide with unknown etiology. This study aimed to investigate the impact and mechanism of RAD6 on the development of Esophageal squamous cell carcinoma...

    Authors: Yu Deng, Yujiang Li, Tiantong Wu, Xuyuan Chen, Xiang Li, Kaican Cai and Xu Wu
    Citation: Biological Procedures Online 2022 24:4
  46. Flower color is one of the main characteristics of ornamental plants. Aurones are light yellow flavonoids produced in the petals of a limited number of plant species including snapdragon (Antirrhinum majus). As a...

    Authors: Amir Rajabi, Leila Fahmideh, Mojtaba Keykhasaber and Valiollah Ghasemi Omran
    Citation: Biological Procedures Online 2022 24:3

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