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A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions
Biological Procedures Online volume 7, pages 101–116 (2005)
Most behavioral experiments within circadian research are based on the analysis of locomotor activity. This paper introduces scientists to chronobiology by explaining the basic terminology used within the field. Furthermore, it aims to assist in designing, carrying out, and evaluating wheel-running experiments with rodents, particularly mice. Since light is an easily applicable stimulus that provokes strong effects on clock phase, the paper focuses on the application of different lighting conditions.
Dunlap JC, Loros JL, DeCoursey PJ. CHRONOBIOLOGY — biological timekeeping. Sinauer Associates 2004; 3(24):67–105.
Pittendrigh CS. On the mechanism of the entrainment of a circadian rhythm by light cycles. In: Circadian clocks; edited by: Aschoff J, Amsterdam: Elsevier (1965); 277–297.
Pittendrigh CS. Circadian systems: entrainment. In: Handbook of behavioral neurobiology, Vol. 4 Biological Rhythms, edited by Aschoff J, New York: Plenum Press (1981); 95–124.
Pittendrigh CS, Daan S. A functional analysis of circadian pacemakers in nocturnal rodents. IV. Entrainment: Pacemaker as clock. J Comp Physiol A 1976; 106:291–331.
Aschoff J, Daan S, Honma KI. Zeitgeber, entrainment, and masking: some unsettled questions. In: Vertebrate Circadian System (Structure and Physiology), edited by Aschoff J, Daan S, Gross GA, Berlin: Springer-Verlag (1982); 13–24.
Takahashi JS, Turek FW, Moore RY. Circadian Clocks. Handbook of Behavioral Neurobiology 2001; 12:7–43.
Fuller CA, Fuller P. Circadian Rhythms. Encyclopedia of the human brain. (2002); 793–812.
Aschoff J. Exogenous and endogenous components in circadian rhythms. Cold Spring Harbor Symp Quant Biol 1960; 25:11–28.
Zheng B, Albrecht U, Kaasik K, Sage M, Lu W, Vaishnav S, Li Q, Sun ZS, Eichele G, Bradley A, Lee CC. Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 2001; 105(5):683–694.
Klante G, Steinlechner S. A short red light pulse during dark phase of LD-cycle perturbs the hamster’s circadian clock. J Comp Physiol 1995; 177(6):775–780.
Hofstetter JR, Hofstetter AR, Hughes AM, Mayeda AR. Intermittent long-wavelength red light increases the period of daily locomotor activity in mice. J Circadian Rhythms 2005; 3(1):8.
Pittendrigh CS, Daan S. A functional analysis of circadian pacemakers in nocturnal rodents. I. The stability and liability of spontaneous frequency. J Comp Physiol A 1976; 106:223–252.
Daan S, Merrow M, Roenneberg T. External time – internal time. J Biol Rhythms 2002; 17 (2):107–109.
Steinlechner S, Jacobmeier B, Scherbarth F, Dernbach H, Kruse F, Albrecht U. Robust circadian rhythmicity of Per1 and Per2 mutant mice in constant light, and dynamics of Per1 and Per2 gene expression under long and short photoperiods. J Biol Rhythms 2002; 17(3):202–209.
Daan S, Pittendrigh CS. A functional analysis of circadian pacemakers in nocturnal rodents. II. The variability of phase response curves. J Comp Physiol A 1976; 106:253–266.
Zivkovic B. Clock tutorial #6: To entrain or not to entrain, that is the question. (2005); http://circadiana.blogspot.com
Albrecht U, Foster RG. Placing ocular mutants into a functional context: a chronobiological approach. Methods 2002; 28:465–477.
Banjanin S, Mrosovsky N. Preferences of mice, Mus musculus, for different types of running wheel. Lab Anim 2000; 34(3):313–318.
Deboer T, Tobler I. Running wheel size influences circadian rhythm period and its phase shift in mice. J Comp Phys 2000; 186(10):969–973.
Brown SA, Zumbrunn G, Flwury-Olela F, Preitner N, Schibler U. Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Curr Biol 2002; 12:1574–1583.
Ingram DK, London ED, Reynolds MA, Waller SB, Goodrick CL. Differential effects of age on motor performance in two mouse strains. Neurobiol Aging 1981; 2(3):221–227.
Valentinuzzi VS, Scarbrough K, Takahashi JS, Turek FW. Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. American Physiol Soc 1997; R1957–R1964.
Aschoff J. Response curves in circadian periodicity. In: Circadian Clocks, edited by Aschoff J, North-Holland Amsterdam (1965); 95–111.
Albrecht U, Oster H. The circadian clock and behavior. Behav Brain Res 2001; 125(1–2):89–91.
Oster H, Baeriswyl S, Van Der Horst GT, Albrecht U. Loss of circadian rhythmicity in aging mPer1-/- mCry2-/- mutant mice. Genes Dev 2003; 17(11):1366–1379.
Albrecht U, Zheng B, Larkin D, Sun ZS, Lee CC. mPer1 and mPer2 are essential for normal resetting of the circadian clock. J Biol Rhythms 2001; 16(2):100–104.
Knutsson A. Health disorders of shift workers. Occup Med (London) 2003, 53(2):103–108.
Filipski E, Delaunay F, King VM, Wu M, Claustrat B, Gréchez-Cassiau A, Guettier C, Hastings MH, Lévi F. Effects of chronic jet lag on tumor progression in mice. Cancer Res 2004; 64:7879–7885.
Ohta H, Yamazaki S, McMahon DG. Constant light desynchronizes mammalian clock neurons. Nat Neurosci 2005; 8(3):267–269.
Aschoff J. Changes of frequency of periods of activity of mice in constant light and lasting darkness. Pflugers Arch 1952; 255(3):197–203.
Kennaway DJ. Resetting the suprachiasmatic nucleus clock. Front Biosci 2004; 9:56–62
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Jud, C., Schmutz, I., Hampp, G. et al. A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions. Biol. Proced. Online 7, 101–116 (2005). https://doi.org/10.1251/bpo109
- Photoperiod, Chronobiology
- Circadian Rhythm