Fig. 1

The neuroprotective effects of D-allose.  A Neurological function was assessed using the mNSS scale 24 and 48 h after ischemia-reperfusion. B Cerebral infarct volumes were measured using TTC staining 24 and 48 h after reperfusion. C Brain edema was measured 24 and 48 h after reperfusion. D Assessment of neurological function after the treatment. E D-allose was administered by intraperitoneal injection within 5 min after reperfusion. TTC staining was performed to evaluate the infarct volumes. F Brain edema was measured after the treatment. G Western blot analysis of apoptosis-related molecules. H TUNEL assay of neuronal apoptosis in mice after MCAO.  The levels of TNF-α (I), IL-1β (J) and IL-6 (K) in cerebral tissue were detected by ELISA kits. ** P<0.01 compared with the Sham group; ^nsP>0.05, ^##P<0.01 compared with the MCAO group. The data were analyzed using one-way ANOVA and Dunnett’s test was used for post hoc analysis. Data were from three independent experiments