Fig. 8

Inhibition of NB progression after treatment of AU1 in vivo. A The workflow of animal experiment. B-C Weight and volume of tumor for nude mice treated intratumorally with BPTF inhibitor AU1 and DMSO at the indicated time points (15 mM, 15ul/animal/3 days; data from 5 mice/group). D Body weight of mice during treatment [mean, 0.805 vs. 0.255]. E Representative images of immunostaining of Ki67 in tumor sections. F The statistical graph of IHC [mean, 2.800 vs. 1.800]. G Schematic diagram showing that BPTF is regulated by TFAP4, activates the PI3K/AKT pathway to promote NB progression, and its clinical application. Error bars represent SEM. * P < 0.05, ** P < 0.01, as assessed by Student’s t-tests