Fig. 6

ABCB10 depletion inhibited the growth and EMT of CC xenograft tumors via miR-128-3p/ZEB1 axis. Mice were randomly divided into sh-ctrl or sh-circ-ABCB10 group with 6 mice per group. C33A cells stably transduced with sh-ctrl or sh-circ-ABCB10 lentiviruses were inoculated into the subcutaneous tissues of mice in sh-ctrl or sh-circ-ABCB10 group, respectively. A The tumor volume was monitored and recorded every 5 days. B At day 30, tumors were resected and weighed. C IHC analyses for Ki67 in xenograft tumors in sh-Ctrl and sh-circ-ABCB10 groups. D MiR-128-3p levels were tested through RT-qPCR assays in xenograft tumors. E ZEB1, E-cadherin, N-cadherin, Vimentin and Snail in xenograft tumors production levels were examined through western blotting assays. *P < 0.05