Fig. 8
From: A rat model for retinitis pigmentosa with rapid retinal degeneration enables drug evaluation in vivo
Analysis of retinas of P347L rats by immunoelectron microscopy. (a) Autophagosomes in retinas of P347L rats at the age of 10 days (i). Immunoelectron microscopy showing co-localization of rhodopsin labeled with gold colloid particles of 5 nm diameter, and LC3 labeled with gold colloid particles of 10 nm diameter, in the vesicles of vehicle group retina (ii) and rapamycin group retina (iii). Scale bar: 0.2 μm; white arrowheads: rhodopsin; black arrowheads: LC3. (b) Rhodopsin counts: 5 nm gold colloid labeled particles in autophagosome area. Graph showing the number of particles in P347L rats with or without rapamycin. Unpaired t test: **p < 0.01