Nasopharyngeal Microbiota in SARS-CoV-2 Positive and Negative Patients

Table 1 Results of analysis of compositions (ANCOM) between COVID-19-positive and -negative nasopharyngeal samples

ANCOM
(Phylum) Genus	Median Percentile Abundance: COVID-19-Negative	Median Percentile Abundance: COVID-19-Positive	W Score
(Firmicutes) Streptococcus	213.92	1.0	19
*Genera trending towards significance*
(Firmicutes) Enterococcus	37.25	292	8
(Proteobacteria) Burkholderia-Caballeronia-Paraburkholderia	1.0	91.33	8
(Proteobacteria) *Gulbenkiania*	1.0	33.67	6
(Firmicutes) *Finegoldia*	121.83	1.0	5
(Firmicutes) *Anaerococcus*	173.42	1.0	4
(Proteobacteria) *Neisseriaceae Uncultured*	371.42	1.0	4
(Firmicutes) Bacillus	47.58	624.67	4
(Bacteroidetes) *Prevotella*	70.58	1.0	3
(Actinobacteria) Corynebacterium	3,434.08	236.67	3

ANCOM: samples with fewer than 5,000 sequences were removed; features that were not present in at least 4 samples were removed; features with an overall count of less than 500 [10% of feature biom – due to small sample size ≤ 10 per group] were also removed. All listed significant features [genus] rejected the null hypothesis. Median percentile abundance (average of the 25^th, 50^th, 75^th percentiles) and analysis W scores determined using ANCOM. ANCOM values were corrected for multiple testing using the Benjamini–Hochberg method (q-value < 0.05: bold). Taxa also identified as significant in DESeq2 analyses are bolded

ISSN: 1480-9222