Recent Advances on Immune Targeted Therapy of Colorectal Cancer Using bi-Specific Antibodies and Therapeutic Vaccines

Table 1 Some of the gene mutations implicated in CRC

Gene	Gene type	Consequence of mutation	References
APC	Tumor suppressor	loss of spindle microtubules regulation and increasing chromosomal instability	[14]
P53	Tumor suppressor	Loss of cell cycle regulation	[15]
RAS, BRAF PIK3CA	Oncogene	Increasing mutation in genes which involved in cell growth through MAPK pathway	[14,15,16]
WT1	Oncogene	significantly associated with tumor progression	[17]
MYH	Base excision repair	Cause somatic mutation of APC.	[18]

ISSN: 1480-9222