Fig. 2
From: Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2
[7]: SARS-CoV-2 and molecular chaperones. a GRP78 or HSPA5 can be part of the ACE2-receptor complex recognized by the SARS-CoV-2 and can modulate virus entry. b ACE2-binding spike must be broken by specific proteases of 3CLpro (3C-like serine protease) or viral PLpro (papain-like cysteine protease) to allow the spike fusion domains to function. 3CLpro, also induces apoptosis thought caspase’s pathways. c Molecular chaperones, such as GRP78 and GRP94, participate in the folding of SARS-CoV-2 proteins. RdRp (RNA-dependentRNA polymerase)