Fig. 2
From: Mutational Analysis of Ocriplasmin to Reduce Proteolytic and Autolytic Activity in Pichia pastoris
The analysis of RMSD (root mean square deviation), RMSF (root-mean-square fluctuations), and center of mass distance between ocriplasmin and substrate throughout the molecular dynamic simulation. a Backbone RMSD are shown as a function of time for wild type and mutant variants. b RMSF of the backbone CAs of C-alpha atoms of wild type and mutant variants. c Comparison distance between center of mass of ocriplasmin and substrate; It shows the effective vicinity of wild type rather than mutant variants of ocriplasmin. Wild type (blue) and mutant variants, proteolytic (red), autolytic (green) and mixed (dark violet) (R. Baghban, unpublished work)