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Table 5 The radiosensitivity level of breast cancer patients, BRCA1/2 mutation carriers and breast cancer patients with radiotherapy complication, using other assays

From: Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays

Reference Marker Sample size Cell type Radiation dose Result
Breast cancer
 Auer et al. 2014 [173] 3-color FISH 1. BC cases (67)
2. Healthy controls (62)
Lymphocyte 2 Gy Spontaneous RS
BC cases ↔ Healthy controls
RS after radiation
BC cases > Healthy controls
 Barwell et al. 2007 [174] Terminal restriction fragment length assay 1. BC cases (212)
2. Healthy controls (1804)
WBC & lymphocyte 1. caesium-137 source at 0.5/1 Gy, or mock
2. caesium-137 source at 4 Gy, or mock
RS after radiation
BC cases ↔ Healthy controls
 West et al. 1995 [172] Colony formation 1. BC cases with acute complication (7)
2. BC cases with late complication (6)
3. BC cases W/O complication (8)
4. Healthy controls (20)
Lymphocyte HDR:
1.55 Gy min-1
LDR:
0.0098 Gy min-1
HDR
RS after radiation
BC cases ↔ Healthy controls
LDR
RS after radiation
BC cases ↔ Healthy controls
Radiotherapy complications
 Oppitz et al. 2002 [158] Colony formation 1. BC cases with elevated acute reactions (6)
2. BC cases with average acute reactions (17)
Fibroblast 5 Gy Spontaneous RS
Elevated acute reactions ↔ Average acute reactions
Radiosensitivity after radiation
Elevated acute reactions ↔ Average acute reactions
 West et al. 1995 [172] Colony formation 1. BC cases with acute complication (7)
2. BC cases with late complication (6)
3. BC cases without complication (8)
4. Healthy controls (20)
Lymphocyte HDR:
1.55 Gy min-1
LDR:
0.0098 Gy min-1
HDR
RS after radiation
BC with acute/late complication ↔ Healthy controls
BC W/O complication ↔ Healthy controls
LDR
RS after radiation
BC with acute/late complication > Healthy controls
BC cases W/O complication ↔ Healthy controls
  1. RS radiosensitivity, BC breast cancer, WBC white blood cell, HDR high dose rate, LDR low dose rate, W/O without, Gr: gray
  2. ↔: no significant differences at the radiosensitivity level, >: significant higher level of radiosensitivity