Isolation and Quantification of Blood Apoptotic Bodies, a Non-invasive Tool to Evaluate Apoptosis in Patients with Ischemic Stroke and Neurodegenerative Diseases

Table 2 Specific proteins identified in apoptotic bodies

Protein function	Protein	Gene	Description
Cytoskeletal protein	Tropomyosin α-4	TPM4	Actin binding motor protein
	β-Parvin	PARVB	Actin related protein
	F-actin-capping	CAPZB	Non-motor actin binding protein
	Profilin-1	PFN1	Non-motor actin binding protein
	Pleckstrin	PLEK	Actin cytoskeleton reorganization
	Tubulin β-1	TUBB1	Major constituent of microtubules
	Tubulin β-4	TUBB4	Major constituent of microtubules
Cell-adhesion molecule	Integrin β-3	ITGB3	Cell-surface protein
Cell-adhesion molecule	Integrin-linked	ILK	Mediator of inside-out integrin signaling kinase
Signaling molecule	Guanine nucleotide binding protein	GNAQ	Heterotrimeric G- protein, membrane signaling modulator
Signaling molecule	Ras-related protein	RAP1B	Small GTPase, signal transduction protein
Glycolytic enzyme	Fructose-2-P-Aldolase	ALDOA	Synthesis of D-glyceraldehyde 3-P and glycerone-P from D-glucose
	Glucose-6-P-Isomerase	GPI	Conversion of glucose-6-P to fructose-6-P
	Triose-P-Isomerase	TPI1	Interconversion between dihydroxyacetone-P and D-glyceraldehyde-3-P
Stress protein and chaperone	Glutathione-S- Transferase omega-1	GSTO1	Mediator of oxidative stress
Stress protein and chaperone	Heat shock 71 kDa protein	HSPA8	Protection of the proteome from stress

Function, name, gene and description of common specific proteins detected by proteomic analysis in apoptotic bodies isolated from neurological patients and healthy controls

ISSN: 1480-9222