Table 2 List of circRNAs related to Cardiovascular Diseases
From: Deep Insights in Circular RNAs: from biogenesis to therapeutics
Disease Type | CircRNA | Targets | Effect on Diseases | Ref. |
|---|---|---|---|---|
Heart failure and pathological hypertrophy | HRCR | mmiR-223, ARC | Suppression | Wang et al., 2016 |
Myocardial Infarction | Cdr1as (ciRS-7) | miR-7, SP1, PARP | Induction | Geng et al., 2016 |
Cardiac senescence | Circ-Foxo3 | ID1,E2F1,FAK,HIF1a | Suppression | Du et al., 2017 |
Atherosclerosis | cANRIL | INK4/ARF locus | Regulation | Song et al., 2017 |
hsa_circ_0003575 | miR-199-3p, miR-9-5p, miR-377-3p and miR-141-3p | Regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis | Li et al., 2017 | |
hsa_circ_0010729 | miR-186/HIF-1α axis | Regulates vascular endothelial cells proliferation and apoptosis | Dang et al., 2017 | |
Cardiomyopathy | Circ-Amotl1 | AKT1 | Regulation | Zeng et al., 2017 |
Myocardial Fibrosis | CircRNA_010567 | miR-141, TGF- β1, Col I, α-SMA and Col III | Promotes Fibrosis | Zhou et al., 2017 |
Coronary artery disease | hsa_circ_0124644 | – | Biomarker | Zhao et al., 2017 |
hsa -circRNA11783–2 | – | No functional role elucidated |