Fig. 3
From: Exploring G Protein-Coupled Receptor Signaling in Primary Pancreatic Islets
Analyzing IP1 response of different Gq/11 protein-coupled receptors expressed in pancreatic islets. a, b Stimulation of receptors highly expressed in pancreatic β cells resulted in a significant increase in IP1 concentration. P2Y6 (a) was stimulated with 10 μM UDP and FFAR2 (b) with 1 mM acetate. c, d Activation of GHS-R expressed in δ cells by 300 nM ghrelin (c) and V1R expressed in α and δ cells by 100 nM AVP (d) did not lead to a significant increase of IP1 concentration. Data are given as means ± SEM of three experiments each performed in triplicates. Statistical significance was tested with a two-tailed paired t test (*p ≤ 0.05; **p ≤ 0.01)