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Table 1 Interpretation of the anti-biofilm effect size based on different scenarios of starting viable cell numbers before treatment

From: MBEC Versus MBIC: the Lack of Differentiation between Biofilm Reducing and Inhibitory Effects as a Current Problem in Biofilm Methodology

  At measured endpoint Scenario A Scenario B Scenario C Scenario D
Pre-antimicrobial exposure Pre- antimicrobial exposure Pre- antimicrobial exposure Pre- antimicrobial exposure
Untreated 108 CFU/mL 105 CFU/mL 107 CFU/mL 108 CFU/mL 109 CFU/mL
Treated 105 CFU/mL 105 CFU/mL 107 CFU/mL 108 CFU/mL 109 CFU/mL
Interpretation 3 log10 biofilm reduction 3 log10 inhibition of biofilm growth (MBIC) 2 log10 biofilm reduction 3 log10 biofilm reduction (MBEC or BBC) 3 log10 biofilm reduction (MBEC or BBC)
  1. MBIC Minimal biofilm inhibitory concentration, MBEC Minimal biofilm eradication concentration, BBC Biofilm bactericidal concentration