An Alternative Model of Laser-Induced Stroke in the Motor Cortex of Rats

Boyko, Matthew; Kuts, Ruslan; Gruenbaum, Benjamin F.; Tsenter, Philip; Grinshpun, Julia; Frank, Dmitry; Zvenigorodsky, Vladislav; Melamed, Israel; Brotfain, Evgeni; Zlotnik, Alexander

doi:10.1186/s12575-019-0097-x

Biological Procedures Online

Table 2 Assessment of brain edema, NSS, subarachnoid hemorrhage and BBB breakdown in non-injured hemisphere. ^a = p < 0.01

From: An Alternative Model of Laser-Induced Stroke in the Motor Cortex of Rats

Groups		BBB n = 10		Brain Edema n = 10		NSS n = 20		Subarachnoid hemorrhage n (%), n = 20
Groups		Mean and SEM	Variability%	Mean and SEM %	Variability%	Mean and SEM	Variability%	Subarachnoid hemorrhage n (%), n = 20
Naive	1 section	63 ± 24	120	−1.4 ± 0.9	675	1 ± 0.3	97	(0%)
	2 section	120 ± 17	44	1.3 ± 2.9	714
	3 section	203 ± 26	41	1.9 ± 2.3	382
	4 section	127 ± 27	67	1 ± 4	1324
	5 section	191 ± 31	52	1.6 ± 2.9	584
	6 section	139 ± 25	56	−0.4 ± 2.1	− 1883
	Total Hemisphere	141 ± 14	31	0.7 ± 1.2	573
Laser 25jx1	1 section	44 ± 36	257	0.9 ± 2.3	780	2 ± 0.5	89	(0%)
	2 section	109 ± 24	69	0.7 ± 2.1	914
	3 section	197 ± 38	61	−1.9 ± 2.9	− 422
	4 section	241 ± 63	82	1.7 ± 2.1	408
	5 section	224 ± 47	66	2.2 ± 2.2	324
	6 section	171 ± 27	50	7 ± 1.7	77
	Total Hemisphere	172 ± 16	29	1.8 ± 0.6	115
Laser 50jx1	1 section	79 ± 51	203	2.8 ± 2.1	234	3 ± 0.6	108	(0%)
	2 section	145 ± 53	117	0.7 ± 3.2	1529
	3 section	150 ± 29	61	2 ± 2.6	415
	4 section	233 ± 83	112	1.6 ± 3.5	696
	5 section	221 ± 96	136	2.4 ± 2.7	359
	6 section	257 ± 124	153	2.8 ± 2.9	327
	Total Hemisphere	173 ± 55	101	2 ± 1.1	175
Laser 50jx2	1 section	132 ± 42	101	2.4 ± 1.4	182	5 ± 0.9^a	81	(0%)
	2 section	186 ± 78	132	1.7 ± 2.4	431
	3 section	146 ± 2	56	1.3 ± 3	719
	4 section	230 ± 51	70	0.7 ± 2.7	1170
	5 section	304 ± 94	98	1.3 ± 2.4	598
	6 section	166 ± 23	44	1.1 ± 2.6	758
	Total Hemisphere	188 ± 40	68	1.4 ± 1.4	319
Laser 50jx5	1 section	271 ± 73^a	86	5.3 ± 1.7	101	13 ± 1.1^a	39	(0%)
	2 section	437 ± 172^a	124	6.3 ± 2.5	128
	3 section	497 ± 210	134	4.5 ± 3	208
	4 section	591 ± 285^a	152	−0.8 ± 3.6	− 1350
	5 section	432 ± 102	75	3.3 ± 2.7	258
	6 section	293 ± 73	78	4.7 ± 2.2	157
	Total Hemisphere	420 ± 94^a	71	3.8 ± 1.1	92
Laser 50jx10	1 section	456 ± 89^a	62	7 ± 1.7	76	16 ± 1.1^a	30	(0%)
	2 section	572 ± 129^a	71	3.6 ± 1.3	111
	3 section	759 ± 273^a	114	4.3 ± 1.4	100
	4 section	658 ± 117^a	56	2.2 ± 1.3	180
	5 section	485 ± 42^a	27	2.4 ± 2.9	381
	6 section	448 ± 70^a	50	0.8 ± 0.7	264
	Total Hemisphere	563 ± 66^a	37	3.4 ± 0.6	58
t-MCAO	1 section	147 ± 92	198	12.3 ± 5.3^a	135	19 ± 1.3^a	34	5^a (20%)
	2 section	410 ± 101^a	78	6.1 ± 3.1	158
	3 section	1001 ± 350^a	111	4.6 ± 2.4	165
	4 section	1643 ± 387^a	74	6 ± 2.4	124
	5 section	1179 ± 163	44	2.1 ± 2.1	314
	6 section	1331 ± 179	42	2.4 ± 2.5	334
	Total Hemisphere	952 ± 184^a	61	5.6 ± 2.2	122
p-MCAO	1 section	196 ± 118	191	13.2 ± 4.6^a	109	20 ± 1.5^a	37	5^a (20%)
	2 section	553 ± 171^a	98	12.9 ± 3.7^a	90
	3 section	944 ± 159^a	53	7.1 ± 3.9^a	173
	4 section	7991 ± 334^a	53	7.4 ± 4.6	199
	5 section	1813 ± 304^a	53	1.6 ± 2.7	537
	6 section	1559 ± 256^a	52	0.1 ± 2.5	12,173
	Total Hemisphere	1176 ± 224^a	45	7 ± 2.6^a	115

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