Table 2 Enriched gene ontology terms in the CCAT1 wild-type versus CCAT1 knockout transcriptomes derived from differentially expressed genes (in the category of biological process)
From: CRISPR/Cas9 Knockout Strategies to Ablate CCAT1 lncRNA Gene in Cancer Cells
ID | Term | Gene Count | p Valuea |
|---|---|---|---|
GO:0042493 | response to drug | 17 | 4.50E-05 |
GO:0055114 | oxidation-reduction process | 24 | 1.30E-04 |
GO:0031295 | T cell costimulation | 7 | 1.80E-03 |
GO:0008283 | cell proliferation | 15 | 3.00E-03 |
GO:0030522 | intracellular receptor signaling pathway | 5 | 3.40E-03 |
GO:0010951 | negative regulation of endopeptidase activity | 8 | 3.90E-03 |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | 9 | 5.60E-03 |
GO:0008285 | negative regulation of cell proliferation | 15 | 6.00E-03 |
GO:0006805 | xenobiotic metabolic process | 6 | 9.20E-03 |
GO:0051897 | positive regulation of protein kinase B signaling | 6 | 1.20E-02 |
GO:0030449 | regulation of complement activation | 4 | 1.30E-02 |
GO:0006081 | cellular aldehyde metabolic process | 3 | 1.30E-02 |
GO:0048013 | ephrin receptor signaling pathway | 6 | 1.40E-02 |
GO:0001822 | kidney development | 6 | 1.40E-02 |
GO:0007612 | learning | 5 | 1.40E-02 |
GO:0032091 | negative regulation of protein binding | 5 | 1.40E-02 |
GO:0046685 | response to arsenic-containing substance | 3 | 1.90E-02 |
GO:0007568 | aging | 8 | 1.90E-02 |
GO:0060337 | type I interferon signaling pathway | 5 | 2.10E-02 |
GO:0042632 | cholesterol homeostasis | 5 | 2.10E-02 |
GO:0043524 | negative regulation of neuron apoptotic process | 7 | 2.20E-02 |
GO:0006954 | inflammatory response | 13 | 2.30E-02 |
GO:0016477 | cell migration | 8 | 2.40E-02 |
GO:0006636 | unsaturated fatty acid biosynthetic process | 3 | 2.50E-02 |
GO:0032570 | response to progesterone | 4 | 2.60E-02 |
GO:0038083 | peptidyl-tyrosine autophosphorylation | 4 | 2.80E-02 |
GO:0008360 | regulation of cell shape | 7 | 2.80E-02 |
GO:0032526 | response to retinoic acid | 4 | 3.00E-02 |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | 6 | 3.00E-02 |
GO:0003057 | regulation of the force of heart contraction by chemical signal | 2 | 3.30E-02 |
GO:0045785 | positive regulation of cell adhesion | 4 | 3.30E-02 |
GO:0042127 | regulation of cell proliferation | 8 | 3.40E-02 |
GO:0031668 | cellular response to extracellular stimulus | 3 | 3.50E-02 |
GO:0009615 | response to virus | 6 | 3.50E-02 |
GO:0030325 | adrenal gland development | 3 | 3.80E-02 |
GO:0071222 | cellular response to lipopolysaccharide | 6 | 3.90E-02 |
GO:0030154 | cell differentiation | 14 | 4.30E-02 |
GO:0014070 | response to organic cyclic compound | 4 | 4.70E-02 |
GO:0070668 | positive regulation of mast cell proliferation | 2 | 4.90E-02 |
GO:0060675 | ureteric bud morphogenesis | 2 | 4.90E-02 |
GO:0006991 | response to sterol depletion | 2 | 4.90E-02 |