From: microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy
miRNAs | Expression levels in ER+ (vs. ER−) breast cancer | Direct miRNA targets [117] |
---|---|---|
let-7a-c/f | High [4] | CDK6, KRAS, NRAS, HRAS, ITGB3, NF2 , HMGA1/2, EWSR1, DICER , AGO1 , LIN28A/B , CASP3/8/9, PARP1, IL6/10, E2F2, CCND1 /2, CDC34, CDC25A, EZH2, WNT1, MAPK4K4, IRS2, IGF1R , TGFBR1, AKT2, MYC , NUMB |
miR-9 | Low [118] | ITGB1, RCOR1, FOXO1/3, CDH1, MAPK1/3, MMP9, TAZ, NOTCH2, HES1, CBX7, E2F1, RAB34, NFKB1, SIRT1, CCNG1, SOCS5, CREB1, DICER1 , NF1 , CXCR4, TGFBR2, BECN1 |
miR-10a/b | MAP3K7, EPHA4 , HOXA1, HOXB3, ACTG1, PTEN , USF2, PIK3CA/G, SERPINE1 , MMP14, NCOR2 , CKDN1A/2A, KLF4, PPARA, NF1 , PLK1, CCNA2, ZEB1 | |
miR-18a/b | High [57] | ESR1 , KRAS, PTEN , CTGF, NR3C1, HIF1A, TGFBR2, SMAD2/4, HSF2, ATM, DICER , BCL2 , IRF2, RUNX1, MEF2D, CBX7, TNFAIP3, FOXN1 |
miR-19a/b | Low [83] | ESR1 , HOXA5, PTEN , CCND1 , ERBB4, ATXN1, KAT2B, SOCS1, TGFBR2, BMPR2, KIT, TLR2, TNF, TNFAIP3, FOXP1, BTG1, PIK3CA, MAP3K5, CUL5, AKT1, FGFR2, HIPK1 |
miR-21 | High [6] | RASGRP1, CDC25A, BCL2 , JAF1, SMARCA4, SPRY2, DUSP10, TIMP3, SOX2/5, MTAP, DOCK5/7, RECK, TGFBR2/3, PTEN , E2F1, TGFBI, SP1 , APAF1, BTG2, PDCD4 , RHOB, BMPR2, NCOA3 , TP63, MSH2/6, TIAM1, EGFR, ERBB2, ICAM1, PPARA, NTF3, COL4A1 , SMAD7, MAP2K3, MAT2A/2B, STAT3, LRP6, FZD6, BMI1, SOCS1, FOXO1, CASP8, VEGFA |
miR-22 | Low [7] | PTMS, ERBB3, ARPC5, BMP7 , PPARA, ESR1 , NCOA1 , HDAC4/6, HMGB1, SP1 , RAB5B, TET2, CDKN1A , WNT1, SIRT1, NET1, TIAM1, MMP14, SNAI1, CXCR2, AKT1, CDK6 |
miR-25 | Low [4] | BCL2L11, CCL26, KLF4, CDKN1C, KAT2B, TP53 , CDH1, MDM2 , PTEN , EZH2, SMAD7, ERBB2 |
miR-26a/b | High [36] | HMGA1/2, CCND2, CCNE1/2, ESR1 , CDK6, CDC6, PTEN , EZH2, SERBP1, SMAD1/4, REB1, MAP3K2, GSK3B, NOS2, CHD1, FGF9, ATM, HGF, IGF1, LIN28B , DNMT3B, WEE1, ADAM17, CHEK1, ITGA5, DUSP4/5, NRAS, E2F2, PTGS2, JAG1, MYC , GATA4, TAB1, RB1, COX2 |
miR-29b | High [36] | TGFB1/3, HDAC4, COL1A1, COL3A1, COL4A1/2 , COL5A2, SP1 , CDK6, PPP1R13B, PTEN , DNMT1, DNMT3A/B, MCL1, BCL2 , VEGFA, TET1/2, CDC42, MMP2/9/15/24, ADAM12, BMP1, HMGA2, GSK3B, INFG, PIK3R1, CCND2, SNAI3, AKT2/3, ITGA6, GATA3 , PDGFRA, PDGRA-C, STAT3, |
miR-30a-d | DTL, SMAD1, CDK6, NOTCH1, BECN1, SNAI1, PIK3CD, PRDM1, ABL1, VIM , ESR2 , RUNX2, BCL9, SOX4, CBX3, TP53 , NCAM1, DNMT1, ITGB3, ATF1, CCND2, CCNE1/2, RPA1, TET1, NOTCH1, KLF9, CAT, ATG12, SERPINE1 , DLL4, PDGFRB, BCL2 , EIF5A2, ADAM12, HOXA1, SOCS1/3, RUNX2, CASP3, PAK1, MCL1, FOXO3, EZH2 | |
miR-93 | CDKN1A , TP53INP1, E2F1, VEGFA, ITGB8, KAT2B, TUSC2, PTEN , LATS2, TGFBR2, DAB2, SMAD7, ZBTB4, CXCL8, PDCD4 , ANG, PTENP1, NEDD4L, MMP3, ZNRF3, FOXA1 | |
miR-106b | Low [4] | ITCH, APP, CDKN1A , E2F1, KAT2B, RB1, PTEN , APC, CASP7, JAK1 , SETD2, SMAD7, STAT3, ZBTB4, TWIST1, HIF1A, TRIM8, RUNX3, DAB2, PTENP1, CYBB, TNFSF10A/11 |
miR-130a | High [4] | HOXA5/10, ATXN1, KLF4, PPARG, ESR1 , DICER1 , RUNX3, RAB5A, SMAD4, TNF, TGFBR2, TGFB1, PPARA, MYC , PTEN , DLL4, MAP3K12, MECP2, MET |
miR-135b | Low [120] | APC, KLF4, CASR, PPP2R5C, LATS2, SMAD5, MID1, MTCH2, BMPR2, TGFBR1, FOXO1 |
miR-142 | Low [4] | RAC1, ARNTL, TGFBR1/2, BOD1, PROM1, ROCK2, CCNT2, TAB2, HMGA1/B1, PTPN23, TP53INP1, IL1A, HSPA1B, SMAD3, ABCG2, LGR5, ZEB1, SIRT1, HIF1A, SOCS1, PTEN , DOCK6 |
miR-145 | High [121] | BNIP3, KLF4/5, SOX2/9, MUC1, CDKN1A , ITGB8, STAT1, YES1, CLINT1, IRS1/2, VEGFA, HOXA9, MYC , FLI1, IFNB1, IGF1R , FZD7, CDK4/6, SERPINE1 , ESR1 , JAG1, NEDD9, PAK4, ERG, NRAS, ADAM17, CDH2, EPAS1, ETS1, CD44, BRAF, SMAD2/3, TGFBR3, CTNND1, SP1/7 , TNFSF13, DDX6, ARF6, ADD3, HMGA2, ROCK1, HDAC11, SENP1, NAIP, TUG1, TGFB2, EGFR, ACTB |
miR-148 | Low [4] | DNMT1/3B, TGIF2, MCL1, IRS1, BCL2 , ITGA5/B8, ROCK1, PIK3CA, NRAS, CSF1, CDC25B, MAP3K4/9, MMP7, WNT1/10B, CDKN1B, SERPINE1 , SMAD2, MET, USP4, STAT3, ALCAM, TGFB2, AKT2, BAX, CYBB, NRP1, |
miR-150 | Low [4] | MYB, MUC4, EGR2, ZEB1, EP300, TP53 , CBL, SP1 , CREB1, STAT1/5B, CTNNB1, NANOG, MMP14, ZNF350, IGF1R , BIRC5 |
miR-155 | Low [4] | TAB2, SOCS1/6, MSH2/6, MLH1, DET1, SMAD1/2/5, ZNF652, ZIC3, BACH1, APC, TRIM32, RHOA, TP53INP1, SPI1, FOXO3, RUNX2, JUN , ETS1, ICAM1, IRAK3, MYB, SKI, SOX6, FADD, BCL6, NOS3, CCND1 , NFKB1, E2F2, MYC , DOCK1, RAD51, PTEN , ERBB2, RPTOR, TFAM, STAT1, SIRT1, TP53 |
miR-185 | Low [36] | RHOA, CDC42, SIX1, DNMT1, EPAS1, ARC, NFATC3, VEGFA, MZB1, HMGA1/2, IGF1R , DUSP4, CASP14, EPHB2, SMAD7, TRIM29, TGFB1, AKT1, CCNE1, CDK6, ATR, EZH2 |
miR-187 | Low [4] | TNF, BCL6, CRMP1, CYP1B1 , FOXA2, ALDH1A3 |
miR-190 | Low [120] | IGF1, PTEN , BCL2 , KCNQ5, MARK2, FOXP2 |
miR-191 | High [36] | MDM4, TMC7, NDST1, SOX4, CDK6/9, SATB1, CEBPB, BASP1, NOTCH2, EGR1, CCND2 |
miR-193b | High [2] | ESR1 , CCND1 , PLAU, PRAP1, MCL1, ETS1, MAX, KRAS, RAD51, MYB, NF1 , SMAD3, STMN1 |
miR-199a/b | High [4] | MET, HIF1A, SMARCA2, CD44, EZH2, IKBKB, MAPK1, JUNB, DDR1, MAP3K11, CAV1/2, ERBB2, ERBB3, MTOR, SIRT1, PTGS2, HSPA5, ATF6, ERN1, CDH1/2, ZHX1, HGF, BECN1, IGF1, NFKB1, VEGFA, SNAI1, GSK3B, WNT2, FZD4/6, JAG1, HK2, TFAM, CCR7, TGFB2, PIK3CD, PAK4, CDK7, ITGA3, YAP1, MAP4K3m TGFBR1, FLT1, KDR, FOXA2, SLC27A1, AKT1, MAPK8/9/14, HES1, SET, DDR1, PAK4, |
miR-206 | MET, NOTCH3 , ESR1 , PAX3, CCND2, CDK4, NR1H3, KRAS, SFRP1, CCND1 , ANXA2, NR4A2, SMAD2, TWF1, CCL2, VEGFA, SOD1, AKT1 | |
miR-212 | Low [36] | RB1, MECP2, TJP1, PEA15, PTCH1, KCNJ2, RBP2, MYC , ACHE, PXN, SOX4, SGK3, SMAD2, MAF, CCNA2/B1, AGO1 |
miR-214 | High [4] | EZH2, XBP1, PTEN , MAP2K3, MAPK1/8, ING4, TWIST1, GALNT7, TP53 , CTNNB1, JAG1, FGFR1, NRAS, BIRC5, CDK3/6, RAB15, E2F2, ITCH, SUFU, CPD, PIM1 |
miR-217 | High [120] | SIRT1, ROBO1, PTEN , EZH2, E2F3, DACH1, FOXO3, PTPN14, DMNT1, IGF1R |
miR-218 | High [120] | LAMB3, RICTOR, BIRC5/6, LASP1, IKBKB, SP1 , VOPP1, ACTN1, ROBO1, SFRP2, HOXB3, DKK2, TOB1, CDK6, BMI1, HMGB1, LEF1, SLIT3, PDGFRA, GLI2, RUNX2, CDH2, TFF1 , EGFR, LGR4, SMO, E2F2, CDC27, KIT, BCL9 |
miR-221 | High [2] | CDKN1B/C, BMF, FOXO3, DICER1 , KIT, TMED7, ETS1, BBC3, DKK2, DDIT4 , TIMP3, ICAM1, FOS, ESR1 , TICAM1, PTEN , TRPS1, WEE1, ZEB2, RB1, APAF1, RECK, SIRT1, MDM2 , MGMT, SOCS1/3, ARF4, CXCL12 , IL6R, BECN1, RUNX1/2, DVL2, PIK3R1, MMP2, RAD51 |
miR-224 | High [4] | KLK10, CXCR4, CDC42, SMAD4, DIO1, NCOA6 , FOSB, API5, CDH1, CASP3/7, ATG5, MTOR, FUT4, KRAS, BCL2 , PAK2 |
miR-299 | Low [120] | CDKN1A , SPP1 , IGF1 |
miR-342 | GEMIN4, BMP7 , DNMT1, ID4, SREBF1/2, CTBP2, BIRC6, E2F1 | |
miR-375 | High [118] | TIMM8A, PDK1, JAK2, YAP1, MTDH, RASD1, SP1 , MAP3K8, LDHB, CIP2A, TP53 , ERBB2, IGF1R , PIK3CA, DEPTOR, RUNX3, MALAT1, MYCN |
miR-519a | Low [124] | CDKN1A , PTEN , YES1, DICER1 , TIMP1, RB1, FOXF2, STAT3 |
miR-520g | Low [122] | VEGFA, SMAD7, MMP2 |