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Table 2 Extraction of drug residues in water and foods of animal origin using ATPS

From: Aqueous two-phase system (ATPS): an overview and advances in its applications

Sample

Drug

ATPS

Detection limit

Average Extraction Efficiency (%)

Recovery (%)

Linear Range (μg mL−1)

Ref.

Water

Roxithromycin

1-butyl-3-methylimidazolium tetrafluoraborate – Na2CO3 (IL – salt)

0.03 μg mL−1

90.7

90.0–90.8

1.00–20.00 μg mL−1

[129]

Water

Sulfamethoxazole

Poly (propylene glycol)400 – NaH2PO4 (polymer – salt)

0.1 μg L−1

99.2

96.0–100.6

2.5–250.0 μg L−1

[169]

Lake Water

Chloramphenicol

1-butyl-3-methylimidazolium chloride – K2HPO4 (IL – salt)

0.1 ng mL−1

98.5

97.1–101.9

0.5–500 ng mL−1

[170]

Feed Water

Milk

Honey

Feed Water

Chloramphenicol

1-butyl-3-methylimidazolium tetrafluoraborate – Na3C6H5O7 (IL – salt)

0.3 ng mL−1

90.1

90.4–102.7

2–1000 ng mL−1

[130]

Milk

Honey

Milk

Ciprofloxacin

Poly (ethylene glycol-ran-propylene glycol) EOPOL31 – K2HPO4 (polymer – salt)

6.8 ng g−1

1st = 97.7

1st = 83.5–90.2

-

[171]

Egg

2nd = 85.6

2nd = 83.8–86.8

Shrimp

Milk

Sulfonamides

1-butyl-3-methylimidazolium tetrafluoraborate – C6H5Na3O7.2H2O (IL – salt)

2.04–2.84 ng mL−1

-

72.32–108.96

8.55–1036.36 ng mL−1

[172]

Honey

Tetracycline (TC)

1-octyl-3-methylimidazolium bromide – sodium dodecyl sulfate (SDS)

TC = 5.8

-

85.5–110.9

TC = 20.1–301.2

[173]

Oxytetracycline (OTC)

OTC = 8.2

OTC = 30.3–303.6

Chloramphenicol (CAP)

CAP = 4.2 μg kg−1

CAP = 20.4–305.4 μg kg−1

Shrimp

Chloramphenicol

Polyoxyethylene lauryl ether (POELE10) – NaH2PO4 (polymer – salt)

0.8 μg kg−1

99.42

98–100.4

0.5–3.00 μg kg−1

[174]