From: Next generation sequencing in cancer research and clinical application
Study Title/Sponsor | NCT#/# Enrolled/Start Date | Condition | Description | Sequencing Technologies |
---|---|---|---|---|
Tumor Specific Plasma DNA in Breast Cancer/Dartmouth-Hitchcock Medical Center | NCT01617915/6/October 2012 | Breast Cancer | Analyze chromosomal rearrangements and genomic alterations | Whole genome sequencing |
Whole Exon Sequencing of Down Syndrome Acute Myeloid Leukemia/Children’s Oncology Group | NCT01507441/10/February 2012 | Leukemia | Examine DNA samples of patients with Leukemia and Down Syndrome and identify DNA alterations | Whole exome Sequencing |
Studying Genes in Samples From Younger Patients with Adrenocortical Tumor/Children’s Oncology Group | NCT01528956/10/February 2012 | Adrenocortical Carcinoma | Study genes from patients with adrenocortical tumor | Whole genome Sequencing |
Feasibility Clinical Study of Targeted and Genome-Wide Sequencing/University Health Network, Toronto | NCT01345513/150/March 2011 | Solid Tumors | Identify gene mutations in cancer patients | Whole genome sequencing |
An Ancillary Pilot Trial Using Whole Genome Sequencing in Patients with Advance Refractor Cancer/Scottsdale Healthcare | NCT01443390/10/September 2011 | Advanced Cancer | Investigate patients with cancer that are using Phase I drugs and its effect on the patient | Whole genome Sequencing |
Cancer Genome Analysis/Seoul National University Hospital | NCT01458604/100/August 2011 | Malignant Tumor | Identify and analyze genetic alterations in tumors for therapeutic agents | Targeted Sequencing, whole exome sequencing and RNA-seq |
RNA Biomarkers in Tissue Samples From Infants with Acute Meyloid Leukemia/Children’s Oncology Group | NCT01229124/20/October 2010 | Leukemia | Analyze tissue samples and identify biomarkers from RNA | RNA-seq |
Molecular Analysis of Solid Tumors/St. Jude Children’s Research Hospital | NCT01050296/360/January 2010 | Pediatric Solid Tumors | Analyze gene expression profiles of tumor and examine genetic alterations | Whole genome Sequencing |
Deep Sequencing of the Breast Cancer Transcriptome/University of Arkansas | NCT01141530/30/Sept 2009 | Breast Cancer | Examine transcriptional regulation and triple negative breast cancer | RNA-seq |