Figure 4
From: Novel mouse mammary cell lines for in vivo bioluminescence imaging (BLI) of bone metastasis
BLI of 66c14 luc and 4T1.2 luc cells in vivo . Tumor bioluminescence intensities from each of the (A) 66c14 luc and (B) 4 T1.2 luc tumor-bearing mice on day 25 after tumor cell injection are shown. 66c14 luc2 and 4 T1.2 luc3 exhibited the highest BLI intensity in vivo (green bars). Sequential images of (C) 66c14 luc2 and (D) 4 T1.2 luc3 tumor-bearing mice imaged ventrally by BLI once a week for 4 weeks are shown. 66c14 luc2 tumors continued to grow while 4 T1.2 luc3 tumors became necrotic between day 25 and 32. Data expressed as photon/sec (mean ± std dev; n=3).