Figure 2

Bone formation in the interphalangeal joint of male DBA/1 hind paw as assessed by X-ray micro-computed tomography (μCT). μCT imaging of the hindpaw forefeet of a 17 week old DBA/1 mouse shows new bone formation in the proximal interphalangeal joint of the 5th toe and late stage onychoperiostitis of the 4th toe. The mouse bones were visualized ex vivo using Skyscan 1172 μCT system and related SkyScan software (Kontich, Belgium). The scanning parameters were 5 μm pixel size, 50 kV, 200 uA, 0.5 mm Al filter. Data images acquired at multiple viewing angles were reconstructed to generate a full 3D representation of the hind paw.