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Table 1 Peptide analogs and their agonist activity in quorum sensing

From: A Method for Structure–Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci

Name of peptide

Amino acid sequencesa

AC50(nM)b

CSP (UA159sp)

SGSLSTFFRLFNRSFTQALGK

25

TPC3 (JH1005sp)

SGTLSTFFRLFNRSFTQA- - -

268

Peptide agonists

  

R9L

SGSLSTFFL LFNRSFTQALGK

32

N12L

SGSLSTFFRLFL RSFTQALGK

30

R13F

SGSLSTFFRLFNF SFTQALGK

26

TPC1

SGSLSTFFRLFNRSFTQALG –

29

TPN2

- - SLSTFFRLFNRSFTQALGK

32

SPA-18

- - SLSTFFRLFNF SFTQALG -

25

  1. aModifications of amino acid residues are in bold and underlined
  2. bThe AC50 values were calculated from a dose–response curve using Graphpad Prism 4
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Biological Procedures Online

ISSN: 1480-9222

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