Figure 2

Each bead models a 10-kDa domain, with an assumed sedimentation coefficient of 1.42 S. The radius of the bead is 1.67 nm, using R _min = 1.42 nm, and adding 0.25 nm for a shell of water. The beads are an approximation to FN-III or Ig domains, which are ~1.7 × 2.8 × 3.5 nm. The sedimentation coefficients of multibead structures were calculated by the formula of Kirkwood/Bloomfield.