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Table 2 Univariate and multivariate analysis of event‐free survival in 91 children with NB

From: BPTF in bone marrow provides a potential progression biomarker regulated by TFAP4 through the PI3K/AKT pathway in neuroblastoma

Variable

Univariate

Multivariate

HR (95%CI)

P-values

HR (95%CI)

P-values

Sex

    

 male

ref

 

ref

 

 female

1.245 (0.652–2.378)

0.506

1.235 (0.618–2.466)

0.550

Age (months)

  < 18

ref

 

ref

 

  ≥ 18

5.383 (1.293–22.412)

0.021*

2.483 (0.573–10.762)

0.224

BPTF

  < 0.331

ref

 

ref

 

  ≥ 0.331

2.160 (1.121–4.161)

0.021*

2.349 (1.146–4.813)

0.020*

MYCN status

 Amplification

3.726 (1.793–7.740)

 < 0.001*

4.408 (2.002–9.705)

 < 0.001*

 Not amplification

ref

 

ref

 

11q23 status

 LOH

2.976 (1.550–5.712)

0.001*

3.068 (1.560–6.035)

0.001*

 No loss

ref

 

ref

 
  1. HR Hazard ratios, MYCN amplification of the MYCN gene, LOH Loss of heterozygosity. * P < 0.05, as assessed by COX regression