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Fig. 7 | Biological Procedures Online

Fig. 7

From: BPTF in bone marrow provides a potential progression biomarker regulated by TFAP4 through the PI3K/AKT pathway in neuroblastoma

Fig. 7

BPTF is highly expressed in NB bone marrow and correlated with clinical progression. A The expression of BPTF was significantly higher in the HR group than in non-high risk [median, 0.428 vs. 0.288, n = 109]. B The expression of BPTF was significantly higher in stage IV children than in stage I/II/III/IVs children [median, 0.446 vs. 0.283, n = 109]. C The expression of BPTF in the group with bone marrow metastasis was significantly higher than that in the group without bone marrow metastasis [median, 0.428 vs. 0.293, n = 109]. D BPTF in children with newly diagnosed NB was significantly higher than that in children with complete remission [median, 0.331 vs. 0.089, n = 125]. E Among the children followed up for more than 15 months, the children with high BPTF NB had a poor prognosis [3-year EFS, 39.3% vs. 67.2%, n = 91]. P = 0.018, by log-rank test. F Correlation analysis of the five genetic variables (n = 109), by Spearman’s correlation coefficient. * P < 0.05, *** P < 0.001, **** P < 0.0001, as assessed by Mann Whitney test

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