Fig. 1

Higher BPTF is associated with poor survival and high malignancy in NB through databases analysis. A The TARGET database suggests that BPTF is highly expressed in NB tissues than in ganglioneuroblastoma [median, 5.038 vs. 4.882, n = 142]. B The GEO database suggests that BPTF is highly expressed in stage IV than in other stage [median, 7.510 vs. 7.284, n = 498]. C-E The BPTF expression of the different transcripts was higher in high-risk group than in low-risk group from the GEO database [median, 15.047 vs. 14.489, 7.553 vs. 7.224, 7.499 vs. 7.271, n = 498]. F-G Poor prognosis of children with NB in high BPTF group (n = 498). P = 0.2859 [5-year EFS, 60.0% vs. 64.9%, F], P = 0.0262 [5-year OS, 73.6% vs. 84.5%, G], by log-rank test. * P < 0.05, ** P < 0.01, **** P < 0.0001, as assessed by Mann Whitney test