Fig. 4

Correlation between TRscore and the tumor immune microenvironment in the IMvigor210 cohort. A Differences in immune cell infiltration between the high- and low-TRscore groups (****p < 0.0001). B Differences in immune function between the high- and low-TRscore groups (**p < 0.01, ****p < 0.0001). C Correlations between TRscore levels, immune cells and tumor-related regulatory pathways. D Correlation between TRscore and the expression of common immune checkpoints. E-I Differences in PDL1 (E), PDL2 (F), CTLA4 (G), IDO1 (H) and GEM (I) expression between the high and low TRscore groups (***p < 0.001)