Fig. 4

The untargeted metabolomics profiling identified the key metabolites in PDTs. A The OPLS-DA 2D score plot showed the distribution of the 20 paired tumor (T) /matched normal (MN) frozen tissues for the untargeted metabolomics analysis. B The Volcano Plot displays the fold change (FC) and p-value of each metabolite. The threshold value for differential metabolites selection is: (1) P < 0.05, (2)|log2FC| > 0. In the volcano plot, compared with MN, differential metabolites (points with red highlight) in the right top corner are increased in T and differential metabolites (points with blue highlight) in the left top corner are decreased in T. C The Boxplot of the top 9 differential metabolites ordered by P-value are shown