Fig. 3

RNA sequencing (RNAseq) identified the dysregulated genes in PDTs. A The Principal components analysis (PCA) analysis showed the tumor was different from the matched normal samples. B The heat map showed around 600 genes that are significantly dysregulated in tumors compared to matched normal samples with cut-off 10 fold and P less than 0.05. C The heat map showed that 47 genes are classed as the FDA-approved drug targets. D The dot plot showed the significant expression difference between MMP11 and FGFR2 in the paired PDTs. E The heat map showed around 46 Wnt/β-catenin signaling pathway-related genes significantly dysregulated in PDTs. F The dot plot showed the significant expression difference between CTNNB1 and PRKCA in the paired PDTs