Fig. 2

Whole Exome Sequencing (WES) identified the critical mutations in PDTs and Immunohistochemistry (IHC) analysis of β-catenin. A A summary of the number of mutations from indicated variant classifications in nine patients. B A summary of the number of mutations from indicated variant types in nine patients. C A summary of the number of base-transition in nine patients. D Comparison of the number of variants among nine patients. Red and green bars represent missense and nonsense mutation, respectively. E Comparison of the number of variants between indicated variant classifications across nine patients. F A summary of the number of variants in indicated genes. The percentage of indicated genes observed with at least one mutation in nine patients was labeled on the right of the bar. G The representative images of IHC staining for β-catenin in different cases with different magnifications