Fig. 2

Correlation between ACE2 and the immune phenotype in BC. A Differences in expression levels of immune-related targets the high and low ACE2 groups in BC. Significance was calculated with Student’s t-test. ****P < 0.0001. B Differences in T cell inflamed scores between the high and low ACE2 groups. The T cell inflamed score is positively related to the response to cancer immunotherapy. Significance was calculated with Student’s t-test. ****P < 0.0001. C, D Mutational landscape in the high and low ACE2 groups. E Differences in TMB levels between the high and low ACE2 groups. Significance was calculated with Student’s t-test. ****P < 0.0001. F Differences in deficiency rates of MMR proteins between the high and low ACE2 groups. Significance was calculated with Pearson’s Chi-squared test. G Differences in IPS scores between the high and low ACE2 groups. Significance was calculated with Student’s t-test. ****P < 0.0001