Fig. 1

ACE2 predicts an inflamed TME in BC. A Expression levels of 122 immunomodulators between the high and low ACE2 groups in BC. B Differences in the levels of TIICs calculated using five algorithms between the high and low ACE2 groups. C Differences in Tumor Purity, ESTIMATE Score, Immune Score, and Stromal Score estimated by the ESTIMATE method between the high and low ACE2 groups. Significance was calculated with Student’s t-test. *P < 0.05, ****P < 0.0001. D Differences in the gene markers of the common TIICs between the high and low ACE2 groups. E Differences in the various steps of the cancer immunity cycle between the high and low ACE2 groups. Significance was calculated with Student’s t-test. ns-P > 0.05, *P < 0.05, ****P < 0.0001. F Correlation between ACE2 and common inhibitory immune checkpoints. Significance was calculated with Pearson correlation analysis. The color reveals the Pearson correlation coefficient