Fig. 6

Photomicrograph of liver sections of negative control group showing a normal hepatocytes (arrows) radiating from the central vein (asterisk). The hepatocytes showing vesicular nuclei (arrowhead), some of it are binucleated (red arrows) and are separated with sinusoids (blue arrow). b Negative control group showing normal portal tract with its structures; branches of portal vein (arrow), hepatic artery (arrowhead) and bile duct (red arrow). c and d are photomicrograph of liver sections of rat that orally administered with EPA; where c showing normal structure of hepatocytes and sinusoids. d Showing normal structure of portal tract. e and f are photomicrograph of liver sections of rat that administered with EPA-NE; where e showing normal structure of hepatocytes and sinusoids. f Showing normal structure of hepatocytes and sinusoids. Some hepatocytes the surround the portal tract exhibit necrotic feature (arrows). (H&E stain, Scale bar: 5 µm)