From: Programmable Biosensors Based on RNA-Guided CRISPR/Cas Endonuclease
System name | Effector | Recognition type | Sensitivity | Specificity | Signal amplification | Quantitative | Multiplex | Time | Readout | Infrastructure requirement | Reference |
---|---|---|---|---|---|---|---|---|---|---|---|
SHERLOCKv1 | LwaCas13a | DNA/Virus RNA | aM | 1 nt | RPA | N | Na | 2–5 h | Fluorescence | Substantial | [54] |
SHERLOCKv2 | LwaCas13a, Cca-Cas13b, Psm-Cas13b | DNA/Virus RNA | zM | 1 nt | RPA | Yb | Y | ~  1 h | Fluorescence, Naked-eye observation | Substantial/Few | [15] |
m1A detection | LbuCas13a | m1A-RNA | fM | 1 nt | N | Y | N | ~ 10 min | Fluorescence | Substantial | [55] |
On-for-all Biosensor | LwaCas13a | Tumor marker miRNA | pM | 1 nt | N | Y | N | ~  4 h | Electrochemical signal | Few | [20] |
POC system | LwaCas13a | Ebola RNA | 20 pfu | 1 nt | N | Y | N | ~  5 min | Fluorescence | Substantial | [14] |
Colorimetric platform | LwaCas13a | Virus RNA | 200 copies | 1 nt | N | Y | N | ~  1 h | Naked eye observation | Few | [13] |