TY - JOUR AU - Baghban, Roghayyeh AU - Farajnia, Safar AU - Ghasemi, Younes AU - Hoseinpoor, Reyhaneh AU - Safary, Azam AU - Mortazavi, Mojtaba AU - Zarghami, Nosratollah PY - 2020 DA - 2020/12/13 TI - Mutational Analysis of Ocriplasmin to Reduce Proteolytic and Autolytic Activity in Pichia pastoris JO - Biological Procedures Online SP - 25 VL - 22 IS - 1 AB - Ocriplasmin (Jetrea) is using for the treatment of symptomatic vitreomacular adhesion. This enzyme undergoes rapid inactivation and limited activity duration as a result of its autolytic nature after injection within the eye. Moreover, the proteolytic activity can cause photoreceptor damage, which may result in visual impairment in more serious cases. SN - 1480-9222 UR - https://doi.org/10.1186/s12575-020-00138-0 DO - 10.1186/s12575-020-00138-0 ID - Baghban2020 ER -