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Table 6 Glance over the ability of different assays in distinguishing the radiosensitivity level among breast cancer patients, BRCA1/2 mutation carriers and breast cancer patients with radiotherapy complication

From: Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays

 

BC cases vs Healthy controls

Healthy BRCA1 mutation carriers vs Healthy controls

Healthy BRCA2 mutation carriers vs Healthy controls

Healthy BRCA1/2 mutation carriers vs Non-carrier subjects from BRCA1/2 families

BC with BRCA1/2 mutation vs BC W/O BRCA1/2 mutation

BRCA2 vs BRCA1

Radiotherphy Complication

G2 MN assay

- - +

+ - + +

+ +

- +

 

+ -

+

G0 MN assay

+ + + + + + +

-

-

-

-

 

- + -

G2 chromosomal assay

+ + + + + + +

+ -

+ +

 

-

 

- -

G0 chromosomal assay

+ +

      

Comet assay

+ - - +

- - -

-

-

  

+ -

H2AX, P53bp biomarkers

+ + +

-

    

+ + - +

  1. BC breast cancer, MN micronucleus, W/O without
  2. + the technique was able to detect the more radiosensitive group
  3. - the technique failed to detect the more radiosensitive group