Reference | Marker | Sample size | Cell type | Dose | Result |
---|---|---|---|---|---|
Chua et al. 2014 [168] | γH2AX/53BP1 | 1. BC cases (16) | Lymphocyte | 4 Gy | Spontaneous RS |
2. Healthy controls (8) | X-rays | BC cases ↔ Healthy controls | |||
Residual RS (24h post-radiation) | |||||
BC cases > Healthy controls | |||||
Djuzenova et al. 2013 [169] | γH2AX | 1. BC cases (57) | PBMC | 0.5 Gy & 2 Gy | Spontaneous RS |
2. Healthy controls (12) | X-rays | BC cases ↔ Healthy controls | |||
Initial RS (0.5 Gy, 30min post-radiation) | |||||
BC cases > Healthy controls | |||||
Residual RS (2 Gy, 24h post-radiation) | |||||
BC cases > Healthy controls | |||||
Djuzenova et al. 2013 [169] | 53BP1 | 1. BC cases (57) | PBMC | 0.5 Gy & 2 Gy | Spontaneous RS |
2. Healthy controls (12) | X-rays | BC cases ↔ Healthy controls | |||
Initial RS (0.5 Gy, 30min post-radiation) | |||||
BC cases ↔ Healthy controls | |||||
Residual (2 Gy, 24h post-radiation) | |||||
BC > Healthy controls | |||||
BRCA1 mutation carriers | |||||
Kotsopoulos et al. 2007 [13] | γ -H2AX | 1. Healthy BRCA1 mutation carriers | Lymphocyte | 2 Gy | Spontaneous RS |
2. Non-carrier controls (25) | γ-rays | Healthy BRCA1 mutation carriers ↔ Non-carrier controls | |||
RS after radiation | |||||
Healthy BRCA1 mutation carriers ↔ Non-carrier controls | |||||
Radiotherapy complications | |||||
Chua et al. 2014 [168] | γH2AX/53BP1 | 1. BC cases with minimal late complication (8) | Lymphocyte | 4 Gy | Spontaneous RS |
X-rays | Marked late complication ↔ Minimal late complication | ||||
2. BC cases with marked late complication (8) | Residual RS (24h post-radiation) | ||||
Marked late complication > Minimal late complication | |||||
Djuzenova et al. 2013 [169] | H2AX | 1. BC cases with adverse acute skin reaction (6) | PBMC | 0.5 Gy & 2 Gy | Spontaneous RS |
X-rays | Adverse acute skin reaction ↔ Normal skin reaction | ||||
2. BC cases with normal skin reaction (31) | Initial RS (0.5 Gy, 30min) | ||||
Adverse acute skin reaction > Normal skin reaction | |||||
Residual RS (2 Gy, 24h post-radiation) | |||||
Adverse acute skin reaction > Normal skin reaction | |||||
Finnon et al. 2012 [143] | H2AX | 1. BC cases with marked adverse reaction (31) | Lymphocyte | 4 Gy | Residual RS (6 h & 24h post-radiation) |
X-rays | Marked adverse reaction ↔ | ||||
2. BC cases with mild late adverse reaction (28) | Mild late adverse reaction | ||||
Chua et al. 2011 [170] | γH2AX/53BP1 | 1. BC cases with severely marked reaction (7) | Lymphocyte | 0.5 and 4 Gy | Initial RS (0.5 Gy, 30min post-radiation) |
X-rays | Severely marked reaction ↔ Minimal skin reaction | ||||
2. BC cases with minimal skin reaction (7) | Residual RS (4 Gy, 24h post-radiation) | ||||
Severely marked reaction > Minimal skin reaction |