Isolation and Quantification of Blood Apoptotic Bodies, a Non-invasive Tool to Evaluate Apoptosis in Patients with Ischemic Stroke and Neurodegenerative Diseases

Table 1 Characteristics of the study patients and controls

Subject code	Neurological disease	Gender	Age	Clinical features at time of blood collection
IS1	Ischemic stroke	Male	82	Acute phase (undetermined etiology), occlusion of left cerebral artery, affected cerebral volume: 57,835 cm³
IS2	Ischemic stroke	Female	55	Acute phase (undetermined etiology), occlusion of right cerebral artery, affected cerebral volume: 45,080 cm³
IS3	Ischemic stroke	Male	57	Acute phase (cardioembolic etiology), occlusion of right cerebral artery, affected cerebral volume: 36,980 cm³
IS4	Ischemic stroke	Male	64	Acute phase (cardioembolic etiology), occlusion of right cerebral artery, affected cerebral volume: 65,605 cm³
MS1	Multiple sclerosis	Female	37	Relapse episode (early RRMS^a type)
MS2	Multiple sclerosis	Female	27	Relapse episode (early RRMS type)
MS3	Multiple sclerosis	Male	34	Relapse episode (early RRMS type)
MS4	Multiple sclerosis	Female	24	Relapse episode (early RRMS type)
PD1	Parkinson’s disease	Female	65	H&Y^b stage II (tremor-dominant type)
PD2	Parkinson’s disease	Female	62	H&Y stage II (tremor-dominant type)
PD3	Parkinson’s disease	Female	71	H&Y stage II (akinetic-rigid type)
PD4	Parkinson’s disease	Male	75	H&Y stage II (akinetic-rigid type)
H1	Control	Male	66	Healthy volunteer
H2	Control	Female	75	Healthy volunteer
H3	Control	Male	82	Healthy volunteer
H4	Control	Female	62	Healthy volunteer
H5	Control	Female	27	Healthy volunteer
H6	Control	Male	36	Healthy volunteer

Subject code, neurological disease, gender, age, clinical features at time of blood collection are shown. ^aRRMS relapsing-remitting multiple sclerosis. ^bH&Y Hoehn and Yahr scale
Blood samples of isquemic patients were obtained within 5 h after symptom onset
Blood extractions of patients with multiple sclerosis was carried out during the first manifestation, while those of patients with Parkinson’s diseases were performed after 7–12 years after diagnosis

ISSN: 1480-9222