Fig. 2

Analysis of the isolated vesicles by transmission electron microscopy. Representative electron micrographs of vesicles obtained from blood samples of stroke, multiple sclerosis and Parkinson’s disease patients and of healthy controls, following the described isolation protocol. All microscopy images show intact particles surrounded by a membrane, although some open membranes could be seen. Electron-dense chromatin substance appears within these rounded shaped vesicles, which have been found to display an average diameter of 1 μm. The morphological features detected in most isolated vesicles are characteristic of apoptotic bodies, a type of extracellular vesicle. Scale bars; 1 μm in the left panel, 500 nm in the right panel