Table 1 The top ten GO analysis and Reactome pathways after infection of 2B4 cell line with SARS-CoV
Top 10 | GO analysis | Reactome enrichment pathways |
|---|---|---|
1 | GO:0005769 (early endosome) | R-HAS-9612973 (autophagy) |
2 | GO:0019904 (protein domain specific binding) | R-HAS-6807070 (PTEN regulation) |
3 | GO:0016192 (vesicle-mediated transport) | R-HAS-5607764 (CLEC7A or Dectin-1 signaling) |
4 | GO:0010008 (endosome membrane) | R-HAS-163200 (respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins) |
5 | GO:0045121 (membrane raft) | R-HAS-4086400 (PCP/CE pathway) |
6 | GO:0006888 (ER to Golgi vesicle-mediated transport) | R-HAS-428157 (sphingolipid metabolism) |
7 | GO:0005085 (guanyl-nucleotide exchange factor activity) | R-HAS-156827 (L13a-mediated translational silencing of Ceruloplasmin expression) |
8 | GO:0006413 (translational initiation) | R-HAS-72706 (GTP hydrolysis and joining of the 60S ribosomal subunit) |
9 | GO:0006886 (intracellular protein transport) | R-HAS-179419 (APC:Cdc20-mediated degradation of cell cycle proteins prior to satisfaction of the cell cycle checkpoint) |
10 | GO:0071013 (catalytic step 2 spliceosome) | R-HAS-72613 (eukaryotic translation initiation) |