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Table 1 List of circRNAs related to Neurological Diseases

From: Deep Insights in Circular RNAs: from biogenesis to therapeutics

Neurological DiseaseCircular RNATargetsMechanismsReferences
Inflammatory Neuropathyhsa-circRNA 2149miR-138Specific expression in leukocytes
Involved in chronic CD28 associated CD8+ T cell aging.
Fu et al., 2015
CircRNA hsa 2149
Balance the expression between Th1 and Th2 through suppressing the function of RUNX3.
Alzheimer’s DiseaseCDR1asmiR-7Downregulate AD relevant targets, such as UBE2A, which plays an important role in clearance of amyloid peptides in AD.Zhao et al., 2016 Lukiw et al., 2016
Nervous system NeoplasmsCDR1-asmiR-7Represses the expression of EGFR, IRS1, & IRS2. Thereby reducing the active and aggressive glioblastoma.Liu et al., 2014
Parkinson’s DiseaseCDR1-asmiR-7Downregulate α-synuclein expression and protect cells against oxidative stress.Junn et al., 2009
Amyotrophic lateral sclerosisKnown and Unknown CircRNAsFUSFUS regulates biogenesis of CircRNAs in mouse Motor Neurons.Errichelli et al., 2017
Systemic lupus erythematosushsa: circ_102584,(hsa-miR-766-3p, hsa-miR-762, hsa-miR-412-3p, hsa-let-7i-3p and hsa- miR-431-3p)Mechanism not clearHaixia et al., 2018
hsa: circ_400011,(hsa-miR-296-3p, hsa-miR-146b-3p, hsa-miR-181d-3p, hsa-miR-504-3p and hsa-miR-328-5p)
hsa: circ_101471(hsa-miR-136-5p, hsa-miR-665, hsa-miR-486-3p, hsa-miR-601 and hsa-miR-30b-3p)
hsa: circ_100226(hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-24-3p, hsa-miR-620 and hsa-miR-875-3p)