Table 1 List of circRNAs related to Neurological Diseases

Inflammatory Neuropathy

hsa-circRNA 2149

miR-138

Specific expression in leukocytes

Involved in chronic CD28 associated CD8^{+ T} cell aging.

Fu et al., 2015

CircRNA hsa 2149

Balance the expression between Th1 and Th2 through suppressing the function of RUNX3.

Alzheimer’s Disease

CDR1as

miR-7

Downregulate AD relevant targets, such as UBE2A, which plays an important role in clearance of amyloid peptides in AD.

Zhao et al., 2016 Lukiw et al., 2016

Nervous system Neoplasms

CDR1-as

miR-7

Represses the expression of EGFR, IRS1, & IRS2. Thereby reducing the active and aggressive glioblastoma.

Liu et al., 2014

Parkinson’s Disease

CDR1-as

miR-7

Downregulate α-synuclein expression and protect cells against oxidative stress.

Junn et al., 2009

Amyotrophic lateral sclerosis

Known and Unknown CircRNAs

FUS

FUS regulates biogenesis of CircRNAs in mouse Motor Neurons.

Errichelli et al., 2017

Systemic lupus erythematosus

hsa: circ_102584,

(hsa-miR-766-3p, hsa-miR-762, hsa-miR-412-3p, hsa-let-7i-3p and hsa- miR-431-3p)

Mechanism not clear

Haixia et al., 2018

hsa: circ_400011,

(hsa-miR-296-3p, hsa-miR-146b-3p, hsa-miR-181d-3p, hsa-miR-504-3p and hsa-miR-328-5p)

hsa: circ_101471

(hsa-miR-136-5p, hsa-miR-665, hsa-miR-486-3p, hsa-miR-601 and hsa-miR-30b-3p)

hsa: circ_100226

(hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-24-3p, hsa-miR-620 and hsa-miR-875-3p)