Table 1 GPCRs tested in this study. Receptors are given in order from high to low expression [33]
From: Exploring G Protein-Coupled Receptor Signaling in Primary Pancreatic Islets
GPCR | Agonist | Coupling properties | Islet expression profile |
|---|---|---|---|
GLP-1R | GLP-1 | Gs | β cell > > α cell > δ cell |
SstR1–5 | somatostatin | Gi | ubiquitous |
P2Y6 | UDP | Gq/11 | β cell > δ cell > > α cell |
M3R | acetylcholine | Gq/11 | β cell > δ cell > α cell |
FFAR2 | acetate | Gi / Gq/11 | ubiquitous |
V1R | AVP | Gq/11 | δ cell = α cell |
GHS-R | ghrelin | Gq/11 | δ cell > > > α cell > β cell |