Fig. 2
From: An Overview of Methods for Reconstructing 3-D Chromosome and Genome Structures from Hi-C Data
Chromosome and genome 3-D structure reconstruction workflow. A summarization of the steps for genome and chromosome 3-D structure taken by the different methods. Starting from the user input in Step 1: The input preparation, usually, Hi-C contact matrix or sometimes with extra parameters requirement. Step 2: One of the three IF modeling approach is used to represent the IF depending on the method’s algorithm. Step 3: Modeling is done using defined sampling algorithms, and Step 4, a consensus average structure or a group of structure is generated depending on the method’s structure class