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Fig. 1 | Biological Procedures Online

Fig. 1

From: Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence

Fig. 1

Tocotrienols have been shown to display beneficial effects in a multitude of age-related conditions related to the accumulation of senescent cells. It has been shown in vitro that tocotrienols may act as senescence delayers (1 – black arrows) by reducing the amount of ROS which, in turn, are a direct trigger of senescence or contribute to replicative and DNA-damage induced senescence. Tocotrienols may additionally inhibit the pathways that drive the production of the SASP (2 – brown arrows) by targeting mTOR and NF-kB. Finally, it has been hypothesized that tocotrienols may promote selective death of senescent cells (senolysis) (3 – red arrows) by increasing endoplasmic reticulum stress or suppressing glycolysis or by other mechanisms that still deserve to be investigated

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