Fig. 1

Representative images of spheroid Geltrex™ degradation. Representative confocal images of UMSCC1 (a) or MDA-MB-231 (b) spheroids causing Geltrex™ degradation signalling at Day 0, 7, and 14 or Day 0, 2, and 4, respectively. Spheroid volume was revealed through bright-field imaging and Geltrex™ degradation through 488 nm excitation/515 emission. c 3D images of MDA-MB-231 cells showing both a spheroid and a background of highly invasive cells that attached to the bottom of the slides. Scale bar, 100 μm. Images are representative of three repetitions