From: microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy
miRNA | Known mechanisms of regulation by estrogen/ERα | References |
---|---|---|
miRNAs upregulated by estrogen/ERα | ||
 let-7a-g/i | Located in the intragenic region of an estradiol-regulated gene | |
 miR-7 |  | |
 miR-9 |  | [131] |
 miR-17 | ERα-induced MYC/c-MYC upregulation; c-MYC interaction with the miR-17-92 promoter | |
 miR-18a |  | [57] |
 miR-19a/b |  | |
 miR-20a | ERα-induced MYC/c-MYC upregulation; c-MYC interaction with the miR-17-92 promoter | |
 miR-21 | Contains ERα binding sites in regulatory region | |
 miR-23a | Contains ERα binding sites in regulatory region | [32] |
 miR-24 |  | [132] |
 miR-25 |  | |
 miR-27b |  | |
 miR-29a |  | [39] |
 miR-30b/c | Located in the intragenic region of an estradiol-regulated gene | [32] |
 miR-32 |  | [57] |
 miR-34c |  | [39] |
 miR-92a/b |  | |
 miR-93 | Requires estrogen metabolism-mediated oxidative stress | |
 miR-98 |  | |
 miR-99b |  | [132] |
 miR-101 |  | [57] |
 miR-103 |  | |
 miR-106a/b |  | |
 miR-107 |  | [32] |
 miR-124 |  | [39] |
 miR-127 |  | [39] |
 miR-129 |  | [59] |
 miR-148a |  | [39] |
 miR-149 |  | [39] |
 miR-181d |  | [39] |
 miR-191 |  | |
 miR-196a | Contains ERα binding site in promoter region | [134] |
 miR-200a-c |  | |
 miR-203 |  | [32] |
 miR-206 |  | [39] |
 miR-210 |  | [39] |
 miR-301a |  | [39] |
 miR-320a/c |  | [132] |
 miR-424 |  | |
 miR-450 |  | [57] |
 miR-489 |  | [57] |
 miR-503 |  | [135] |
 miR-542 |  | [57] |
 miR-638 |  | [132] |
 miR-1275 |  | [132] |
 miR-1915 |  | [132] |
miRNAs downregulated by estrogen/ERα | ||
 let-7a/c/f/g | Transcriptionally repressed by estradiol-induced ER | |
 miR-9 | Located in the intragenic region of an estradiol-regulated gene | [32] |
 miR-15b |  | [132] |
 miR-21 | Mediated by AF-1; Transcriptionally repressed by estradiol-induced ER; Contains ERα binding sites in promoter/regulatory region; Mediated by unliganded ERα | |
 miR-22 |  | |
 miR-23b | Transcriptionally repressed by estradiol-induced ER | [40] |
 miR-26a/b |  | |
 miR-27a/b | Contains ERα binding sites in regulatory region; Transcriptionally repressed by estradiol-induced ER | |
 miR-127 |  | [59] |
 miR-143 |  | [32] |
 miR-148a |  | [136] |
 miR-181a/b/d | Contains ERα binding sites in regulatory region; Transcriptionally repressed by estradiol-induced ER; Mediated by unliganded ERα | |
 miR-198 |  | [57] |
 miR-200c |  | [40] |
 miR-206 |  | [13] |
 miR-221/222 | Contains ERα binding sites in promoter region | [12] |
 miR-302b |  | [32] |
 miR-487b |  | [57] |
 miR-494 |  | [57] |
 miR-500 |  | [57] |
 miR-506 |  | [32] |
 miR-519e |  | [8] |
 miR-524 |  | [32] |
 miR-584 |  | [57] |
 miR-663 |  | [57] |
 miR-671 |  | [57] |
 miR-1228 |  | [8] |
 miR-1826 |  | [132] |