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Table 3 miRNAs regulated by estrogen/ERα activation

From: microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy

miRNA Known mechanisms of regulation by estrogen/ERα References
miRNAs upregulated by estrogen/ERα
 let-7a-g/i Located in the intragenic region of an estradiol-regulated gene [32, 57]
 miR-7   [8, 39]
 miR-9   [131]
 miR-17 ERα-induced MYC/c-MYC upregulation; c-MYC interaction with the miR-17-92 promoter [32, 39, 57, 59]
 miR-18a   [57]
 miR-19a/b   [8, 57]
 miR-20a ERα-induced MYC/c-MYC upregulation; c-MYC interaction with the miR-17-92 promoter [8, 39, 57, 59]
 miR-21 Contains ERα binding sites in regulatory region [32, 39, 44, 57, 59]
 miR-23a Contains ERα binding sites in regulatory region [32]
 miR-24   [132]
 miR-25   [39, 57]
 miR-27b   [39, 67]
 miR-29a   [39]
 miR-30b/c Located in the intragenic region of an estradiol-regulated gene [32]
 miR-32   [57]
 miR-34c   [39]
 miR-92a/b   [57, 59, 132]
 miR-93 Requires estrogen metabolism-mediated oxidative stress [57, 132, 133]
 miR-98   [32, 57]
 miR-99b   [132]
 miR-101   [57]
 miR-103   [32, 132]
 miR-106a/b   [8, 57, 59]
 miR-107   [32]
 miR-124   [39]
 miR-127   [39]
 miR-129   [59]
 miR-148a   [39]
 miR-149   [39]
 miR-181d   [39]
 miR-191   [39, 132]
 miR-196a Contains ERα binding site in promoter region [134]
 miR-200a-c   [32, 132]
 miR-203   [32]
 miR-206   [39]
 miR-210   [39]
 miR-301a   [39]
 miR-320a/c   [132]
 miR-424   [32, 57]
 miR-450   [57]
 miR-489   [57]
 miR-503   [135]
 miR-542   [57]
 miR-638   [132]
 miR-1275   [132]
 miR-1915   [132]
miRNAs downregulated by estrogen/ERα
 let-7a/c/f/g Transcriptionally repressed by estradiol-induced ER [40, 132]
 miR-9 Located in the intragenic region of an estradiol-regulated gene [32]
 miR-15b   [132]
 miR-21 Mediated by AF-1; Transcriptionally repressed by estradiol-induced ER; Contains ERα binding sites in promoter/regulatory region; Mediated by unliganded ERα [40,41,42,43,44, 132]
 miR-22   [57, 59]
 miR-23b Transcriptionally repressed by estradiol-induced ER [40]
 miR-26a/b   [40, 132]
 miR-27a/b Contains ERα binding sites in regulatory region; Transcriptionally repressed by estradiol-induced ER [32, 40, 57]
 miR-127   [59]
 miR-143   [32]
 miR-148a   [136]
 miR-181a/b/d Contains ERα binding sites in regulatory region; Transcriptionally repressed by estradiol-induced ER; Mediated by unliganded ERα [40, 57, 137]
 miR-198   [57]
 miR-200c   [40]
 miR-206   [13]
 miR-221/222 Contains ERα binding sites in promoter region [12]
 miR-302b   [32]
 miR-487b   [57]
 miR-494   [57]
 miR-500   [57]
 miR-506   [32]
 miR-519e   [8]
 miR-524   [32]
 miR-584   [57]
 miR-663   [57]
 miR-671   [57]
 miR-1228   [8]
 miR-1826   [132]