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Table 3 miRNAs regulated by estrogen/ERα activation

From: microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy

miRNA

Known mechanisms of regulation by estrogen/ERα

References

miRNAs upregulated by estrogen/ERα

 let-7a-g/i

Located in the intragenic region of an estradiol-regulated gene

[32, 57]

 miR-7

 

[8, 39]

 miR-9

 

[131]

 miR-17

ERα-induced MYC/c-MYC upregulation; c-MYC interaction with the miR-17-92 promoter

[32, 39, 57, 59]

 miR-18a

 

[57]

 miR-19a/b

 

[8, 57]

 miR-20a

ERα-induced MYC/c-MYC upregulation; c-MYC interaction with the miR-17-92 promoter

[8, 39, 57, 59]

 miR-21

Contains ERα binding sites in regulatory region

[32, 39, 44, 57, 59]

 miR-23a

Contains ERα binding sites in regulatory region

[32]

 miR-24

 

[132]

 miR-25

 

[39, 57]

 miR-27b

 

[39, 67]

 miR-29a

 

[39]

 miR-30b/c

Located in the intragenic region of an estradiol-regulated gene

[32]

 miR-32

 

[57]

 miR-34c

 

[39]

 miR-92a/b

 

[57, 59, 132]

 miR-93

Requires estrogen metabolism-mediated oxidative stress

[57, 132, 133]

 miR-98

 

[32, 57]

 miR-99b

 

[132]

 miR-101

 

[57]

 miR-103

 

[32, 132]

 miR-106a/b

 

[8, 57, 59]

 miR-107

 

[32]

 miR-124

 

[39]

 miR-127

 

[39]

 miR-129

 

[59]

 miR-148a

 

[39]

 miR-149

 

[39]

 miR-181d

 

[39]

 miR-191

 

[39, 132]

 miR-196a

Contains ERα binding site in promoter region

[134]

 miR-200a-c

 

[32, 132]

 miR-203

 

[32]

 miR-206

 

[39]

 miR-210

 

[39]

 miR-301a

 

[39]

 miR-320a/c

 

[132]

 miR-424

 

[32, 57]

 miR-450

 

[57]

 miR-489

 

[57]

 miR-503

 

[135]

 miR-542

 

[57]

 miR-638

 

[132]

 miR-1275

 

[132]

 miR-1915

 

[132]

miRNAs downregulated by estrogen/ERα

 let-7a/c/f/g

Transcriptionally repressed by estradiol-induced ER

[40, 132]

 miR-9

Located in the intragenic region of an estradiol-regulated gene

[32]

 miR-15b

 

[132]

 miR-21

Mediated by AF-1; Transcriptionally repressed by estradiol-induced ER; Contains ERα binding sites in promoter/regulatory region; Mediated by unliganded ERα

[40,41,42,43,44, 132]

 miR-22

 

[57, 59]

 miR-23b

Transcriptionally repressed by estradiol-induced ER

[40]

 miR-26a/b

 

[40, 132]

 miR-27a/b

Contains ERα binding sites in regulatory region; Transcriptionally repressed by estradiol-induced ER

[32, 40, 57]

 miR-127

 

[59]

 miR-143

 

[32]

 miR-148a

 

[136]

 miR-181a/b/d

Contains ERα binding sites in regulatory region; Transcriptionally repressed by estradiol-induced ER; Mediated by unliganded ERα

[40, 57, 137]

 miR-198

 

[57]

 miR-200c

 

[40]

 miR-206

 

[13]

 miR-221/222

Contains ERα binding sites in promoter region

[12]

 miR-302b

 

[32]

 miR-487b

 

[57]

 miR-494

 

[57]

 miR-500

 

[57]

 miR-506

 

[32]

 miR-519e

 

[8]

 miR-524

 

[32]

 miR-584

 

[57]

 miR-663

 

[57]

 miR-671

 

[57]

 miR-1228

 

[8]

 miR-1826

 

[132]