Table 2 miRNAs that regulate ESR1/ERα
From: microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy
miRNA | Effects on ESR1/ERα and known mechanisms of ER regulation | References |
|---|---|---|
miR-1 | Suppresses ESR1 expression | [7] |
miR-9 | Suppresses ESR1 expression ➢ Directly targets ESR1 | |
miR-18a/b | Suppresses ESR1 expression ➢ Directly targets ESR1 Inhibits ERα transcriptional activity | |
miR-19a/b | Suppresses ESR1 expression ➢ Directly targets ESR1 Inhibits ERα transcriptional activity | [57] |
miR-20a/b | Suppresses ESR1 expression ➢ Directly targets ESR1 ➢ Directly targets NCOA3 Inhibits ERα transcriptional activity | [57] |
miR-22 | Suppresses ESR1 expression ➢ Directly targets ESR1 ➢ Directly targets SP1 | |
miR-26a/b | Suppresses ESR1 expression ➢ Directly targets ESR1 | |
miR-93 | Suppresses ESR1 expression | [11] |
miR-103 | Suppresses ESR1 expression | [7] |
miR-107 | Suppresses ESR1 expression | [7] |
miR-122 | Suppresses ESR1 expression | [7] |
miR-129 | Suppresses ESR1 expression | [7] |
miR-130a/b | Suppresses ESR1 expression | |
miR-145 | Suppresses ESR1 expression, but does not affect ESR1 or ERα stability ➢ Directly targets ESR1 | [128] |
miR-146b | Suppresses ESR1 expression | [7] |
miR-181a-d | Suppresses ESR1 expression | [11] |
miR-192 | Suppresses ESR1 expression ➢ Directly targets ESR1 | [129] |
miR-193b | Suppresses ESR1 expression ➢ Directly targets NCOA3 | |
miR-206 | Suppresses ESR1 expression and ER target genes ➢ Directly targets ESR1 ➢ Directly targets NCOA1 and NCOA3 ➢ Directly targets GATA3 ➢ Directly targets MET | |
miR-219 | Suppresses ESR1 expression | [11] |
miR-221 | Suppresses ESR1 expression ➢ Directly targets ESR1 | |
miR-222 | Suppresses ESR1 expression ➢ Directly targets ESR1 | |
miR-301a/b | Suppresses ESR1 expression | [11] |
miR-302a-e | Suppresses ESR1 expression | [11] |
miR-335 | Suppresses ESR1 expression ➢ Directly targets ESR1 | [130] |
miR-372 | Suppresses ESR1 expression | [11] |
miR-373 | Suppresses ESR1 expression | [11] |
miR-517a/c | Suppresses ESR1 expression | [11] |
miR-520a-e | Suppresses ESR1 expression | [11] |
miR-548p | Suppresses ESR1 expression | [7] |
miR-583 | Suppresses ESR1 expression | [7] |
miR-590 | Suppresses ESR1 expression | [7] |
miR-643 | Suppresses ESR1 expression | [7] |
miR-874 | Suppresses ESR1 expression | [7] |
miR-885 | Suppresses ESR1 expression | [7] |
miR-934 | Suppresses ESR1 expression | [7] |
miR-1231 | Suppresses ESR1 expression | [7] |