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Table 2 miRNAs that regulate ESR1/ERα

From: microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy

miRNA Effects on ESR1/ERα and known mechanisms of ER regulation References
miR-1 Suppresses ESR1 expression [7]
miR-9 Suppresses ESR1 expression
➢ Directly targets ESR1
[7, 11, 125]
miR-18a/b Suppresses ESR1 expression
➢ Directly targets ESR1
Inhibits ERα transcriptional activity
[7, 11, 57, 82]
miR-19a/b Suppresses ESR1 expression
➢ Directly targets ESR1
Inhibits ERα transcriptional activity
[57]
miR-20a/b Suppresses ESR1 expression
➢ Directly targets ESR1
➢ Directly targets NCOA3
Inhibits ERα transcriptional activity
[57]
miR-22 Suppresses ESR1 expression
➢ Directly targets ESR1
➢ Directly targets SP1
[7,8,9, 11]
miR-26a/b Suppresses ESR1 expression
➢ Directly targets ESR1
[126, 127]
miR-93 Suppresses ESR1 expression [11]
miR-103 Suppresses ESR1 expression [7]
miR-107 Suppresses ESR1 expression [7]
miR-122 Suppresses ESR1 expression [7]
miR-129 Suppresses ESR1 expression [7]
miR-130a/b Suppresses ESR1 expression [7, 11]
miR-145 Suppresses ESR1 expression, but does not affect ESR1 or ERα stability
➢ Directly targets ESR1
[128]
miR-146b Suppresses ESR1 expression [7]
miR-181a-d Suppresses ESR1 expression [11]
miR-192 Suppresses ESR1 expression
➢ Directly targets ESR1
[129]
miR-193b Suppresses ESR1 expression
➢ Directly targets NCOA3
[11, 125]
miR-206 Suppresses ESR1 expression and ER target genes
➢ Directly targets ESR1
➢ Directly targets NCOA1 and NCOA3
➢ Directly targets GATA3
➢ Directly targets MET
[1, 7, 11,12,13,14]
miR-219 Suppresses ESR1 expression [11]
miR-221 Suppresses ESR1 expression
➢ Directly targets ESR1
[8, 11]
miR-222 Suppresses ESR1 expression
➢ Directly targets ESR1
[7, 8, 11]
miR-301a/b Suppresses ESR1 expression [11]
miR-302a-e Suppresses ESR1 expression [11]
miR-335 Suppresses ESR1 expression
➢ Directly targets ESR1
[130]
miR-372 Suppresses ESR1 expression [11]
miR-373 Suppresses ESR1 expression [11]
miR-517a/c Suppresses ESR1 expression [11]
miR-520a-e Suppresses ESR1 expression [11]
miR-548p Suppresses ESR1 expression [7]
miR-583 Suppresses ESR1 expression [7]
miR-590 Suppresses ESR1 expression [7]
miR-643 Suppresses ESR1 expression [7]
miR-874 Suppresses ESR1 expression [7]
miR-885 Suppresses ESR1 expression [7]
miR-934 Suppresses ESR1 expression [7]
miR-1231 Suppresses ESR1 expression [7]