From: Cancer chemoprevention and therapy using chinese herbal medicine
Chinese Drug name | Chemoprevention model in vitro | Traditional application | Potential Active Components |
---|---|---|---|
Green tea | DMBA or UVB-induced skin papillomas in CD-1 mice [5] | Traditional Chinese drinks | |
N-nitrosomethylbenzylamine (NMBzA) oesophageal tumor caused by in rats [6] | |||
N-nitrosodiethylamine(NDEA)-induced forestomach and lung cancer in A/J mice [7] | |||
UVB-induced skin tumor in SKH-1 mice 8 [89] | |||
NNK induced lung cancer in A/J mice [90] | |||
N-Methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats [91] | |||
B[a]P-induced lung cancer in A/J mice [8] | |||
NDEA-induced lung tumorigenesis in A/J mice [7] | |||
Transgenic adenocarcinoma of the mouse prostate (TRAMP) model [92, 93] | |||
NNK-induced lung cancer in A/J mice [94] | |||
N-ethyl-N′-nitro-N-nitrosoguanidine (ENNG)-induced duodenal tumors in C57BL/6 J mice [95] | |||
UVB-induced skin tumors [94] | |||
Prunella vulgaris | B[a]P-induced lung cancer in A/J mice [10] | Diabetics | Quercetin [96] |
B[a]P, 1,6-dinitropyrene and 3,9-dinitrofluoranthene [97] | Â | ||
Rosmarinic acid (Effective Components extracted from Salvia miltiorrhiza) | DMBA-induced oral carcinogenesis in golden Syrian hamsters [12] | Coronary artery disease, gastric ulcer and tumor | NA |
 | DMBA-induced skin carcinogenesis in Swiss albino mice [13] |  |  |
Ginseng | B[a]P-induced lung cancer in A/J mice [8] | Chronic lung disease, antioxidant and tumor | 20(S)-Protopanaxadiol [100] Ginsenoside-Rh2 [101, 102] Ginsenoside F2 [103] Ginsenoside-Rb1 [104] |
DMBA, urethane, and aflatoxin B1-induced Lung cancer in ICR newborn mice [19] | |||
NTCU-induced lung SCC in Swiss mice [20] | |||
DMBA-induced chromosomal aberra-tions and micronuclei [21] | |||
TPA-induced skin tumor in ICR mice [105] | |||
Scutellaria barbata | DMBA and TPA-induced skin tumor in female (C57BL/6XC3H) F1 (B6C3F1) mice [22] | Tumor | Scutellaria barbata polysaccharide [106] Scutellarin [107] BZL101 (FDA IND# 59,521 [108] |
Curcumin | Azoxymethane-induced rat colon carcinogenesis [24] | Antioxidant and | NA |
(extracted from Turmeric) | 4NQO-induced oral carcinogenesis [26] DMBA-induced oral carcinogenesis in hamsters [109] | anti-inflammatory | Â |
Honiokial | male nude mice implanted with PC-3 cells [110] | Constipation and | NA |
 | UVB-induced skin cancer in mice [14] | abdominal distension |  |
DMBA-initiated and TPA-promoted skin cancer in SKH-1 mice [15] | |||
UVB-induced skin cancer in SKH-1 mice [16] | |||
NTCU-induced lung SCC in Swiss mice [18] | |||
Magnolol Magnolol (extracted from Mangnolia officinalis) | Constipation and abdominal distension | NA | |
ATB (Formula contains Sophora tonkinensis, Polygonum bistorta, Prunella vulgaris, Sonchus brachyotus, Dictamnus dasycarpus, and Dioscorea bulbifera) | N-butyl-(4-hydroxybutyl) nitrosamine (BBN)-induced precancerous lesions of the bladder in rats [27] B[a]P-induced in A/J mice harboring a dominant-negative p53 mutation and/or a heterozygous deletion of Ink4a/Arf [29] NTCU-induced lung SCC in Swiss mice [31] 4NQO-induced oral SCC in A/J mice [30] DMBA-induced buccal pouch carcinogenesis in hamsters [32] | Tumor | Sophocarpine [112, 113], Epigallocatechin,gallate [114],Quercetin [96], Ursolic acid [98],Luteolin [99] Obacunone [115] Psoralen [116] |
Liu-Wei-Di-Huang Wan (Formula contains Rehmannia glutinosa, Cornus officinalis Sieb., Common Yam Rhizome, Alisma orientalis, Tree Peony Bark, and Poria cocos) | DMBA-induced lung cancer in mice Urethane-induced lung cancer in mice [34] | Osteoporosis, Alzheimer disease, hypertension, and diabetes | Catalpol [117, 118], Ursolic acid [98],Triterpenes [119], Paeonol [120, 121] Paeoniflorin [122] Pachymic acid [123, 124] |