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Table 1 Chinese Herbs in Chemoprevention Models

From: Cancer chemoprevention and therapy using chinese herbal medicine

Chinese Drug name Chemoprevention model in vitro Traditional application Potential Active Components
Green tea DMBA or UVB-induced skin papillomas in CD-1 mice [5] Traditional Chinese drinks Epicatechin-3-gallate [83, 84]
N-nitrosomethylbenzylamine (NMBzA) oesophageal tumor caused by in rats [6] Epigallocatechin gallate [85, 86]
N-nitrosodiethylamine(NDEA)-induced forestomach and lung cancer in A/J mice [7] Epigallocatechin-3-gallate [87, 88]
UVB-induced skin tumor in SKH-1 mice 8 [89]
NNK induced lung cancer in A/J mice [90]
N-Methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats [91]
B[a]P-induced lung cancer in A/J mice [8]
NDEA-induced lung tumorigenesis in A/J mice [7]
Transgenic adenocarcinoma of the mouse prostate (TRAMP) model [92, 93]
NNK-induced lung cancer in A/J mice [94]
N-ethyl-N′-nitro-N-nitrosoguanidine (ENNG)-induced duodenal
tumors in C57BL/6 J mice [95]
UVB-induced skin tumors [94]
Prunella vulgaris B[a]P-induced lung cancer in A/J mice [10] Diabetics Quercetin [96]
B[a]P, 1,6-dinitropyrene and 3,9-dinitrofluoranthene [97]   Ursolic acid [98] Luteolin [99]
Rosmarinic acid
(Effective Components extracted from Salvia miltiorrhiza)
DMBA-induced oral carcinogenesis in golden Syrian hamsters [12] Coronary artery disease, gastric ulcer and tumor NA
  DMBA-induced skin carcinogenesis in Swiss albino mice [13]   
Ginseng B[a]P-induced lung cancer in A/J mice [8] Chronic lung disease, antioxidant and tumor 20(S)-Protopanaxadiol [100] Ginsenoside-Rh2 [101, 102]
Ginsenoside F2 [103]
Ginsenoside-Rb1 [104]
DMBA, urethane, and aflatoxin B1-induced Lung cancer in ICR newborn mice [19]
NTCU-induced lung SCC in Swiss mice [20]
DMBA-induced chromosomal aberra-tions and micronuclei [21]
TPA-induced skin tumor in ICR mice [105]
Scutellaria barbata DMBA and TPA-induced skin tumor in female (C57BL/6XC3H)
F1 (B6C3F1) mice [22]
Tumor Scutellaria barbata polysaccharide [106] Scutellarin [107]
BZL101 (FDA IND# 59,521 [108]
Curcumin Azoxymethane-induced rat colon carcinogenesis [24] Antioxidant and NA
(extracted from Turmeric) 4NQO-induced oral carcinogenesis [26]
DMBA-induced oral carcinogenesis in hamsters [109]
anti-inflammatory  
Honiokial male nude mice implanted with PC-3 cells [110] Constipation and NA
  UVB-induced skin cancer in mice [14] abdominal distension  
DMBA-initiated and TPA-promoted skin cancer in SKH-1 mice [15]
UVB-induced skin cancer in SKH-1 mice [16]
NTCU-induced lung SCC in Swiss mice [18]
Magnolol Magnolol
(extracted from Mangnolia officinalis)
UVB-induced skin cancer in mice [16, 111] Constipation and abdominal distension NA
ATB
(Formula contains Sophora tonkinensis, Polygonum bistorta, Prunella vulgaris, Sonchus brachyotus, Dictamnus dasycarpus, and Dioscorea bulbifera)
N-butyl-(4-hydroxybutyl) nitrosamine (BBN)-induced precancerous lesions of the bladder in rats [27]
B[a]P-induced in A/J mice harboring a dominant-negative p53 mutation and/or a heterozygous deletion of Ink4a/Arf [29]
NTCU-induced lung SCC in Swiss mice [31]
4NQO-induced oral SCC in A/J mice [30]
DMBA-induced buccal pouch carcinogenesis in hamsters [32]
Tumor Sophocarpine [112, 113], Epigallocatechin,gallate [114],Quercetin [96], Ursolic acid [98],Luteolin [99] Obacunone [115] Psoralen [116]
Liu-Wei-Di-Huang Wan (Formula contains Rehmannia glutinosa, Cornus officinalis Sieb., Common Yam Rhizome, Alisma orientalis, Tree Peony Bark, and Poria cocos) DMBA-induced lung cancer in mice
Urethane-induced lung cancer in mice [34]
Osteoporosis, Alzheimer disease, hypertension, and diabetes Catalpol [117, 118], Ursolic acid [98],Triterpenes [119], Paeonol [120, 121] Paeoniflorin [122] Pachymic acid [123, 124]
  1. NA: not applicable