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Table 1 Chinese Herbs in Chemoprevention Models

From: Cancer chemoprevention and therapy using chinese herbal medicine

Chinese Drug name

Chemoprevention model in vitro

Traditional application

Potential Active Components

Green tea

DMBA or UVB-induced skin papillomas in CD-1 mice [5]

Traditional Chinese drinks

Epicatechin-3-gallate [83, 84]

N-nitrosomethylbenzylamine (NMBzA) oesophageal tumor caused by in rats [6]

Epigallocatechin gallate [85, 86]

N-nitrosodiethylamine(NDEA)-induced forestomach and lung cancer in A/J mice [7]

Epigallocatechin-3-gallate [87, 88]

UVB-induced skin tumor in SKH-1 mice 8 [89]

NNK induced lung cancer in A/J mice [90]

N-Methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats [91]

B[a]P-induced lung cancer in A/J mice [8]

NDEA-induced lung tumorigenesis in A/J mice [7]

Transgenic adenocarcinoma of the mouse prostate (TRAMP) model [92, 93]

NNK-induced lung cancer in A/J mice [94]

N-ethyl-N′-nitro-N-nitrosoguanidine (ENNG)-induced duodenal

tumors in C57BL/6 J mice [95]

UVB-induced skin tumors [94]

Prunella vulgaris

B[a]P-induced lung cancer in A/J mice [10]

Diabetics

Quercetin [96]

B[a]P, 1,6-dinitropyrene and 3,9-dinitrofluoranthene [97]

 

Ursolic acid [98] Luteolin [99]

Rosmarinic acid

(Effective Components extracted from Salvia miltiorrhiza)

DMBA-induced oral carcinogenesis in golden Syrian hamsters [12]

Coronary artery disease, gastric ulcer and tumor

NA

 

DMBA-induced skin carcinogenesis in Swiss albino mice [13]

  

Ginseng

B[a]P-induced lung cancer in A/J mice [8]

Chronic lung disease, antioxidant and tumor

20(S)-Protopanaxadiol [100] Ginsenoside-Rh2 [101, 102]

Ginsenoside F2 [103]

Ginsenoside-Rb1 [104]

DMBA, urethane, and aflatoxin B1-induced Lung cancer in ICR newborn mice [19]

NTCU-induced lung SCC in Swiss mice [20]

DMBA-induced chromosomal aberra-tions and micronuclei [21]

TPA-induced skin tumor in ICR mice [105]

Scutellaria barbata

DMBA and TPA-induced skin tumor in female (C57BL/6XC3H)

F1 (B6C3F1) mice [22]

Tumor

Scutellaria barbata polysaccharide [106] Scutellarin [107]

BZL101 (FDA IND# 59,521 [108]

Curcumin

Azoxymethane-induced rat colon carcinogenesis [24]

Antioxidant and

NA

(extracted from Turmeric)

4NQO-induced oral carcinogenesis [26]

DMBA-induced oral carcinogenesis in hamsters [109]

anti-inflammatory

 

Honiokial

male nude mice implanted with PC-3 cells [110]

Constipation and

NA

 

UVB-induced skin cancer in mice [14]

abdominal distension

 

DMBA-initiated and TPA-promoted skin cancer in SKH-1 mice [15]

UVB-induced skin cancer in SKH-1 mice [16]

NTCU-induced lung SCC in Swiss mice [18]

Magnolol Magnolol

(extracted from Mangnolia officinalis)

UVB-induced skin cancer in mice [16, 111]

Constipation and abdominal distension

NA

ATB

(Formula contains Sophora tonkinensis, Polygonum bistorta, Prunella vulgaris, Sonchus brachyotus, Dictamnus dasycarpus, and Dioscorea bulbifera)

N-butyl-(4-hydroxybutyl) nitrosamine (BBN)-induced precancerous lesions of the bladder in rats [27]

B[a]P-induced in A/J mice harboring a dominant-negative p53 mutation and/or a heterozygous deletion of Ink4a/Arf [29]

NTCU-induced lung SCC in Swiss mice [31]

4NQO-induced oral SCC in A/J mice [30]

DMBA-induced buccal pouch carcinogenesis in hamsters [32]

Tumor

Sophocarpine [112, 113], Epigallocatechin,gallate [114],Quercetin [96], Ursolic acid [98],Luteolin [99] Obacunone [115] Psoralen [116]

Liu-Wei-Di-Huang Wan (Formula contains Rehmannia glutinosa, Cornus officinalis Sieb., Common Yam Rhizome, Alisma orientalis, Tree Peony Bark, and Poria cocos)

DMBA-induced lung cancer in mice

Urethane-induced lung cancer in mice [34]

Osteoporosis, Alzheimer disease, hypertension, and diabetes

Catalpol [117, 118], Ursolic acid [98],Triterpenes [119], Paeonol [120, 121] Paeoniflorin [122] Pachymic acid [123, 124]

  1. NA: not applicable